Fine-Needle Aspiration Diagnosis of High Grade Adenoid Cystic Carcinoma Metastatic to the Pancreas

被引:7
作者
David, Doina [1 ]
Masineni, Sreeharsha N. [1 ]
Giorgadze, Tamar [1 ]
机构
[1] Wayne State Univ, Sch Med, Detroit Med Ctr, Dept Pathol & Lab Med, Detroit, MI USA
关键词
FNA; pancreas; metastasis; adenoid cystic carcinoma; OF-THE-LITERATURE;
D O I
10.1002/dc.23128
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Pancreatic tumors are mostly primary tumors, with only rare metastatic tumors described in the literature. Here we report an unusual case of fine-needle aspiration (FNA) diagnosis of high grade adenoid cystic carcinoma of the parotid gland metastatic to the pancreas. The aspirate smears were moderately cellular and revealed numerous basaloid neoplastic cells. The cytomorphologic differential diagnosis included primary pancreatic tumor with small cell morphology as well as metastatic tumors. By immunocytochemistry, the tumor cells were positive for cytokeratins (AE1/AE3, CAM5.2, and CK7), and CD117 (C-KIT), and negative for CD45, WT1, synaptophysin, chromogranin, CD56, TTF-1, and CK20. The cytomorphologic features and immunoprofile in our case were consistent with high-grade carcinoma metastases from patient's known salivary gland primary. To the best of our knowledge, this case is the first reported encounter of FNA diagnosis of pancreatic metastasis with small cell morphology from a salivary gland neoplasm as primary site. Diagn. Cytopathol. 2015;43:117-120. (c) 2014 Wiley Periodicals, Inc.
引用
收藏
页码:117 / 120
页数:4
相关论文
共 10 条
[1]   Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature [J].
Adsay, NV ;
Andea, A ;
Basturk, O ;
Kilinc, N ;
Nassar, H ;
Cheng, JD .
VIRCHOWS ARCHIV, 2004, 444 (06) :527-535
[2]  
ANDERSON RJ, 1985, ACTA CYTOL, V29, P527
[3]   Endoscopic ultrasound-guided fine-needle aspiration diagnosis of merkel cell carcinoma metastatic to the pancreas [J].
Bernstein, Jane ;
Adeniran, Adebowale J. ;
Cai, Guoping ;
Theoharis, Constantine G. A. ;
Ustun, Berrin ;
Beckman, Danita ;
Aslanian, Harry R. ;
Harigopal, Malini .
DIAGNOSTIC CYTOPATHOLOGY, 2014, 42 (03) :247-252
[4]  
Elsheikh TM, 1997, AM J CLIN PATHOL, V108, pS12
[5]   Endoscopic ultrasound-guided fine-needle aspiration of metastases to the pancreas: A study of 25 cases [J].
Gilbert, Christopher M. ;
Monaco, Sara E. ;
Cooper, Scott T. ;
Khalbuss, Walid E. .
CYTOJOURNAL, 2011, 8
[6]   Metastases to the Pancreas Diagnosed by Fine-Needle Aspiration [J].
Olson, Matthew T. ;
Wakely, Paul E., Jr. ;
Ali, Syed Z. .
ACTA CYTOLOGICA, 2013, 57 (05) :473-480
[7]   Adenoid cystic carcinoma with high-grade transformation: A report of 11 cases and a review of the literature [J].
Seethala, Raja R. ;
Hunt, Jennifer L. ;
Baloch, Zubair W. ;
LiVolsi, Virginia A. ;
Barnes, E. Leon .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2007, 31 (11) :1683-1694
[8]   Metastases in the pancreas from nonhematologic neoplasms: Report of 20 cases evaluated by fine-needle aspiration [J].
Volmar, KE ;
Jones, CK ;
Xie, HB .
DIAGNOSTIC CYTOPATHOLOGY, 2004, 31 (04) :216-220
[9]  
Yu GH, 1996, DIAGN CYTOPATHOL, V15, P296, DOI 10.1002/(SICI)1097-0339(199611)15:4<296::AID-DC9>3.0.CO
[10]  
2-C