The utility of intensified environmental surveillance for pathogenic moulds in a stem cell transplantation ward during construction work to monitor the efficacy of HEPA filtration

被引:33
作者
Nihtinen, A.
Anttila, V-J
Richardson, M.
Meri, T.
Volin, L.
Ruutu, T.
机构
[1] Univ Helsinki, Cent Hosp, Dept Med, Helsinki 00029, Finland
[2] Haartman Inst, Dept Bacteriol & Immunol, Helsinki, Finland
关键词
aspergillus; haematopoietic stem cell transplantation; construction; HEPA filters; environmental sampling;
D O I
10.1038/sj.bmt.1705749
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
A 12-week environmental study was performed to ensure that the patient rooms of an SCT ward with high-efficiency particulate air (HEPA) filtration remained uncontaminated by moulds during close-by construction work. The sampling included measuring the ventilation channel pressure, particle count measurements, air sampling, settled dust analysis and fungal cultures from the oral and nasal cavities of the patients. No changes in the air pressure occurred. Median particle counts in patient rooms were 63-420 particles/l. The mean particle count of the outside air was 173 659 particles/l. Patient room air samples were negative for aspergilli in 32 of 33 cases. All samples of the outside air were positive for moulds. Aspergillus fumigatus was isolated at the beginning of excavation works at the construction area and in two of 33 dust samples from patient rooms. All 70 nasal samples were negative. Of 35 mouth samples, one sample was positive for A. niger in a patient with a previously diagnosed aspergillus infection. During a median follow-up of 214 days, no invasive aspergillus infections were diagnosed in the 55 patients treated during the construction period. In conclusion, the HEPA filters seemed to have performed well in preventing an aspergillosis outbreak.
引用
收藏
页码:457 / 460
页数:4
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