Atrial Natriuretic Peptide31-67: A Novel Therapeutic Factor for Cardiovascular Diseases

被引:7
作者
da Silva, Gustavo Jose Justo [1 ,2 ]
Altara, Raffaele [1 ,2 ,3 ]
Booz, George W. [4 ]
Cataliotti, Alessandro [1 ,2 ]
机构
[1] Oslo Univ Hosp, Expt Med Res Inst, Oslo, Norway
[2] Univ Oslo, Oslo, Norway
[3] Univ Mississippi, Med Ctr, Sch Med, Dept Pathol, Jackson, MS 39216 USA
[4] Univ Mississippi, Med Ctr, Sch Med, Dept Pharmacol & Toxicol, Jackson, MS 39216 USA
来源
FRONTIERS IN PHYSIOLOGY | 2021年 / 12卷
关键词
natriuretic peptides; atrial natriuretic peptide; cardiovascular disease; heart Failure; CONGESTIVE-HEART-FAILURE; PRESERVED EJECTION FRACTION; E-2 RECEPTOR EP4; C-TYPE; PROSTAGLANDIN E-2; VESSEL DILATOR; FACTOR PROHORMONE; HEMODYNAMIC-RESPONSES; CLEARANCE RECEPTORS; SEQUENCE-ANALYSIS;
D O I
10.3389/fphys.2021.691407
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The characterization of the cardiac hormone atrial natriuretic peptide (ANP(9)(9)(-)(1)(26)), synthesized and secreted predominantly by atrial myocytes under stimulation by mechanical stretch, has established the heart as an endocrine organ with potent natriuretic, diuretic, and vasodilating actions. Three additional distinct polypeptides resulting from proteolytic cleavage of proANP have been identified in the circulation in humans. The mid-sequence proANP fragment 31-67 (also known as proANP(3)(1)(-)(6)(7)) has unique potent and prolonged diuretic and natriuretic properties. In this review, we report the main effects of this circulating hormone in different tissues and organs, and its mechanisms of actions. We further highlight recent evidence on the cardiorenal protective actions of chronic supplementation of synthetic proANP(3)(1)(-)(6)(7) in preclinical models of cardiorenal disease. Finally, we evaluate the use of proANP(3)(1)(-)(6)(7) as a new therapeutic strategy to repair end-organ damage secondary to hypertension, diabetes mellitus, renal diseases, obesity, heart failure, and other morbidities that can lead to impaired cardiac function and structure.
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页数:13
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