Palladium/L-Proline-Catalyzed Enantioselective α-Arylative Desymmetrization of Cyclohexanones

被引：101

作者：

Liu, Ren-Rong ^{[1
]}

Li, Bao-Le ^{[1
]}

Lu, Jun ^{[1
]}

Shen, Chong ^{[1
]}

Gao, Jian-Rong ^{[1
]}

Jia, Yi-Xia ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 16期

基金：

中国国家自然科学基金;

关键词：

HETEROCYCLIC CARBENE LIGANDS; TRANSITION-METAL; CROSS-COUPLINGS; ALLYLIC ALKYLATION; DUAL CATALYSIS; ARYL HALIDES; ALDEHYDES; ALLYLATION; KETONES; AMINE;

D O I：

10.1021/jacs.6b01214

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly enantioselective palladium/L-proline-catalyzed alpha-arylative desymmetrization of cyclohexanones was developed. The new strategy for alpha-arylation reaction led to a series of optically active morphan derivatives bearing a-carbonyl tertiary stereo centers in good yields with excellent enantioselectivities (up to 99% ee).

引用

页码：5198 / 5201

页数：4

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