The role of inositol trisphosphate-induced Ca2+ release from IP3-receptor in the rat suprachiasmatic nucleus on circadian entrainment mechanism

被引：42
作者：
Hamada, T
Liou, SY
Fukushima, T
Maruyama, T
Watanabe, S
Mikoshiba, K
Ishida, N
机构：
[1] MITI, Agcy Ind Sci & Technol, Ishida Grp Clock Gene, Natl Inst Biosci & Human Technol, Tsukuba, Ibaraki 3058566, Japan
[2] Nippon Glaxo Ltd, Tsukuba Res Labs, Pharmacol, Tsukuba, Ibaraki 30042, Japan
[3] Kyushu Univ 62, Fac Pharmaceut Sci, Dept Pharmacol, Fukuoka 8128582, Japan
[4] Univ Tokyo, Inst Med Sci, Dept Mol Microbiol, Minato Ku, Tokyo 108, Japan
来源：
NEUROSCIENCE LETTERS | 1999年 / 263卷 / 2-3期
关键词：
inositol trisphosphate receptor; Ca2+; rat suprachiasmatic nucleus; 2-amino-ethoxy diphenylbolate; suprachiasmatic nucleus field potential; suprachiasmatic nucleus firing rhythm; suprachiasmatic nucleus slice culture;
D O I：
10.1016/S0304-3940(99)00111-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Synchronization between the environmental lighting cycle and the circadian clock in the suprachiasmatic nucleus (SCN) is correlated with Ca2+ increase. The mechanism underlying the increase of Ca2+ and its relation to clock resetting are unknown. To address these issues, we examined the possibility whether inositol 1,4,5-trisphosphate receptor (IP3-R), which regulate intracellular Ca2+, was involved in the circadian rhythm component of the rat SCN. A novel IP3-induced Ca2+ release modulator, 2-amino-ethoxy diphenylborate (2APB), blocked optic nerve stimulation-induced neuronal field potentials in the SCN. Furthermore, glutamate-induced phase delay of the circadian firing pattern in the SCN was also blocked completely by 2APB in vitro. Together, these data suggest the possibility that IP3-induced Ca2+ release through IP3-R plays a role in the entrainment of the mammalian circadian clock, the SCN. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：125 / 128
页数：4
相关论文
共 20 条
[1]   INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS - DISTINCT NEURONAL AND NONNEURONAL FORMS DERIVED BY ALTERNATIVE SPLICING DIFFER IN PHOSPHORYLATION [J].
DANOFF, SK ;
FERRIS, CD ;
DONATH, C ;
FISCHER, GA ;
MUNEMITSU, S ;
ULLRICH, A ;
SNYDER, SH ;
ROSS, CA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (07) :2951-2955
[2]   A neuronal ryanodine receptor mediates light-induced phase delays of the circadian clock [J].
Ding, JM ;
Buchanan, GF ;
Tischkau, SA ;
Chen, D ;
Kuriashkina, L ;
Faiman, LE ;
Alster, JM ;
McPherson, PS ;
Campbell, KP ;
Gillette, MU .
NATURE, 1998, 394 (6691) :381-384
[3]   RESETTING THE BIOLOGICAL CLOCK - MEDIATION OF NOCTURNAL CIRCADIAN SHIFTS BY GLUTAMATE AND NO [J].
DING, JM ;
CHEN, D ;
WEBER, ET ;
FAIMAN, LE ;
REA, MA ;
GILLETTE, MU .
SCIENCE, 1994, 266 (5191) :1713-1717
[4]   The role of glutamate in the photic regulation of the suprachiasmatic nucleus [J].
Ebling, FJP .
PROGRESS IN NEUROBIOLOGY, 1996, 50 (2-3) :109-&
[5]   The involvement of calmodulin and Ca2+/calmodulin-dependent protein kinase II in the circadian rhythms controlled by the suprachiasmatic nucleus [J].
Fukushima, T ;
Shimazoe, T ;
Shibata, S ;
Watanabe, A ;
Ono, M ;
Hamada, T ;
Watanabe, S .
NEUROSCIENCE LETTERS, 1997, 227 (01) :45-48
[6]   INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-MEDIATED CA2+ SIGNALING IN THE BRAIN [J].
FURUICHI, T ;
MIKOSHIBA, K .
JOURNAL OF NEUROCHEMISTRY, 1995, 64 (03) :953-960
[7]   LITHIUM SLOWS RAT CIRCADIAN ACTIVITY RHYTHMS [J].
KRIPKE, DF ;
WYBORNEY, VG .
LIFE SCIENCES, 1980, 26 (16) :1319-1321
[8]  
KRIPKE DF, 1979, BIOL PSYCHIAT, V14, P545
[9]  
Maruyama T, 1997, BIOMED RES-TOKYO, V18, P297
[10]  
Maruyama T, 1997, J BIOCHEM-TOKYO, V122, P498
12