FeCl3-Catalyzed Ring-Closing Carbonyl-Olefin Metathesis

被引：90

作者：

Ma, Lina ^{[1
]}

Li, Wenjuan ^{[1
]}

Xi, Hui ^{[1
]}

Bai, Xiaohui ^{[1
]}

Ma, Enlu ^{[1
]}

Yan, Xiaoyu ^{[1
]}

Li, Zhiping ^{[1
]}

机构：

[1] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 35期

基金：

美国国家科学基金会;

关键词：

alkenes; carbocycles; heterocycles; iron; metathesis; ORGANIC-SYNTHESIS; PHOTOPROTOLYTIC OXAMETATHESIS; HETEROCYCLES; ALKYLIDENE; KETONES;

D O I：

10.1002/anie.201604349

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Exploiting catalytic carbonyl-olefin metathesis is an ongoing challenge in organic synthesis. Reported herein is an FeCl3-catalyzed ring-closing carbonyl-olefin metathesis. The protocol allows access to a range of carbo-/heterocyclic alkenes with good efficiency and excellent trans diastereoselectivity. The methodology presents one of the rare examples of catalytic ring-closing carbonyl-olefin metathesis. This process is proposed to take place by FeCl3-catalyzed oxetane formation followed by retro-ring-opening to deliver metathesis products.

引用

页码：10410 / 10413

页数：4

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