Biomarkers to personalize treatment with 177Lu-PSMA-617 in men with metastatic castration-resistant prostate cancer-a state of the art review

被引：21

作者：

Heidegger, Isabel ^{[1
]}

Kesch, Claudia ^{[2
]}

Kretschmer, Alexander ^{[3
]}

Tsaur, Igor ^{[4
]}

Ceci, Francesco ^{[5
]}

Valerio, Massimo ^{[6
]}

Tilki, Derya ^{[7
,8
,9
]}

Marra, Giancarlo ^{[10
]}

Preisser, Felix ^{[11
]}

Fankhauser, Christian D. ^{[12
]}

Zattoni, Fabio ^{[13
]}

Chiu, Peter ^{[14
]}

Puche-Sanz, Ignacio ^{[15
]}

Olivier, Jonathan ^{[16
]}

van den Bergh, Roderik C. N. ^{[17
]}

Kasivisvanathan, Veeru ^{[18
]}

Pircher, Andreas ^{[19
]}

Virgolini, Irene ^{[20
]}

Gandaglia, Giorgio ^{[21
,22
]}

机构：

[1] Med Univ Innsbruck, Dept Urol, Urol, A-6020 Innsbruck, Austria

[2] Essen Univ Hosp, Dept Urol, Essen, Germany

[3] Ludwig Maximilians Univ Munchen, Dept Urol, Munich, Germany

[4] Mainz Univ Med, Dept Urol & Pediat Urol, Mainz, Germany

[5] IRCCS, Div Nucl Med, IEO European Inst Oncol, Milan, Italy

[6] Lausanne Univ Hosp, Dept Urol, Lausanne, Switzerland

[7] Univ Med Ctr Hamburg Eppendorf, Martini Klin Prostate Canc Ctr, Hamburg, Germany

[8] Univ Med Ctr Hamburg Eppendorf, Dept Urol, Hamburg, Germany

[9] Koc Univ Hosp, Dept Urol, Istanbul, Turkey

[10] Univ Torino, San Giovanni Battista Hosp, Dept Urol, Turin, Italy

[11] Univ Hosp Frankfurt, Dept Urol, Frankfurt, Germany

[12] Luzerner Kantonssspital, Luzern, Switzerland

[13] Azienda Sanitaria Univ Integrata Udine, Urol Unit, Udine, Italy

[14] Chinese Univ Hong Kong, Fac Med, Dept Surg, Hong Kong, Peoples R China

[15] Univ Granada, Hosp Univ Virgende las Nieves, Biohlth Res Inst, Dept Urol, Granada, Spain

[16] CHUV Lausanne, Dept Urol, Lausanne, Switzerland

[17] Antonius Hosp, Dept Urol, Utrecht, Netherlands

[18] UCL, Div Surg & Intervent Sci, London, England

[19] Med Univ Innsbruck, Dept Internal Med 5, Hematol & Oncol, Innsbruck, Austria

[20] Med Univ Innsbruck, Dept Nucl Med, Innsbruck, Austria

[21] IRCCS Osped San Raffaele, Urol Res Inst, Div Oncol, Milan, Italy

[22] IRCCS Osped San Raffaele, Urol Res Inst, Unit Urol, Milan, Italy

来源：

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | 2022年 / 14卷

关键词：

177Lu-PSMA-617 radioligand therapy; biomarkers; mCRPC; LU-177-PSMA-617 RADIOLIGAND THERAPY; VISCERAL METASTASES; ANTIGEN; PREDICTORS; SURVIVAL; PSMA; EXPRESSION; OUTCOMES; TUMOR;

D O I：

10.1177/17588359221081922

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radioligand therapy with Lutetium-177 (177Lu)-Prostate-specific membrane antigen (PSMA) has shown to prolong survival in metastatic castration resistant prostate cancer (mCRPC). One of the major challenges for clinicians in the future is to select those patients who would benefit most from this therapy to position it in the treatment landscape of mCRPC. This, in turn, will lead to the delivery of personalized therapies. In this narrative review article we summarize recent studies investigating both predictive and prognostic clinical, imaging-based, and molecular biomarkers to predict treatment response to 177Lu-PSMA-617 radioligand therapy with the aim of identifying men who should be considered for this approach. Of note, the evidence on the role of biomarkers currently relies on small retrospective trials and their validation in larger prospective cohorts is necessary before these results can be translated in the clinical practice.

引用

页数：10

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