Is It Safe to Use a Diuretic to Treat Seizures Early in Development?

被引：10

作者：

Ben-Ari, Y. ^{[1
]}

Tyzio, R. ^{[1
]}

机构：

[1] INSERM, U901, INMED, Marseilles, France

来源：

EPILEPSY CURRENTS | 2011年 / 11卷 / 06期

关键词：

CATION-CHLORIDE COTRANSPORTERS; IMMATURE NEURONS; EXCITATORY GABA; EDEMA FORMATION; K-CL; KCC2; BUMETANIDE; NKCC1; MODEL; BRAIN;

D O I：

10.5698/1535-7511-11.6.192

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There has been considerable interest in using bumetanide, a diuretic chloride importer NKCC1 antagonist, to reduce intracellular chloride ([Cl-](i)) in epileptic neurons, thereby shifting the polarity of GABA from excitatory to inhibitory and ameliorating the actions of GABA-acting antiepileptic drugs. However, a recent study raises the important issue of potential deleterious actions of bumetanide on immature neurons, because reduction of (Cl-)(i) also alleviates a major source of excitation in developing neurons, upon which GABA exerts a trophic action. This review considers the importance of separating intrauterine from postnatal effects of bumetanide in normal versus pathologic neurons.

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收藏

页码：192 / 195

页数：4

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