Ca2+-operated transcriptional networks:: Molecular mechanisms and in vivo models

被引：126
作者：
Mellstrom, Britt [1 ]
Savignac, Magali [1 ]
Gomez-Villafuertes, Rosa [1 ]
Naranjo, Jose R. [1 ]
机构：
[1] CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain
来源：
PHYSIOLOGICAL REVIEWS | 2008年 / 88卷 / 02期
关键词：
D O I：
10.1152/physrev.00041.2005
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Calcium is the most universal signal used by living organisms to convey information to many different cellular processes. In this review we present well-known and recently identified proteins that sense and decode the calcium signal and are key elements in the nucleus to regulate the activity of various transcriptional networks. When possible, the review also presents in vivo models in which the genes encoding these calcium sensors-transducers have been modified, to emphasize the critical role of these Ca2+-operated mechanisms in many physiological functions.
引用
收藏
页码：421 / 449
页数：29
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