The functions of N6-methyladenosine (m6A) RNA modifications in colorectal cancer

被引：12
作者：
Qiao, Haiyan [1 ]
Liu, Linfeng [1 ]
Chen, Jun [2 ]
Shang, Bingbing [1 ,3 ]
Wang, Liang [1 ]
机构：
[1] Dalian Med Univ, Comparat Med Dept Researching & Teaching, Dalian 116044, Liaoning, Peoples R China
[2] Dalian Med Univ, Lab Anim Ctr, Dalian 116044, Liaoning, Peoples R China
[3] Dalian Med Univ, Hosp 1, Emergency Dept, Dalian 116027, Liaoning, Peoples R China
来源：
MEDICAL ONCOLOGY | 2022年 / 39卷 / 12期
关键词：
Colon cancer; Rectal cancer; Colorectal cancer; m6A RNA modifications functions; PROLIFERATION; TRANSLATION; METASTASIS; REGULATORS; COLITIS; CELLS;
D O I：
10.1007/s12032-022-01827-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancers (CRC), which includes colon cancer (CC) and rectal cancer (RC), are some of the most common malignant tumors that are prone to distant metastasis. Its high incidence rate and high mortality rate have attracted much attention. In recent years, epigenetics has attracted increasing attention and has been the focus of many research studies. N6-methyladenosine(m6A) RNA modifications can modify eukaryotic mRNA to impact metabolism. The changes in the m6A regulatory genes are related to the occurrence and development of CRC and play an important role in the pathogenesis of CRC. The effect of m6A RNA modification is regulated by its related regulatory factors ("writer", "eraser", "reader"). In this review, we comprehensively analyzed the effect of m6A methylation on CRC and the relationship between the expression of related regulatory factors and the development and occurrence of CRC. Then, we summarized the roles of m6A and its regulatory factors in CRC and its potential clinical value, which provides a basis for further research on the mechanism of m6A methylation in CRC.
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页数：12
相关论文
共 70 条
[1]   YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma [J].
Bai, Yang ;
Yang, Chunxing ;
Wu, Runliu ;
Huang, Lihua ;
Song, Shenlei ;
Li, Wanwan ;
Yan, Peichen ;
Lin, Changwei ;
Li, Daojiang ;
Zhang, Yi .
FRONTIERS IN ONCOLOGY, 2019, 9
[2]  
Boland CR, 1998, CANCER RES, V58, P5248
[3]   N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization [J].
Chen, Chen ;
Yuan, Weitang ;
Zhou, Quanbo ;
Shao, Bo ;
Guo, Yuying ;
Wang, Weiwei ;
Yang, Shuaixi ;
Guo, Yaxin ;
Zhao, Luyang ;
Dang, Qin ;
Yang, Xiuxiu ;
Wang, Guixian ;
Kang, Qiaozhen ;
Ji, Zhenyu ;
Liu, Jinbo ;
Sun, Zhenqiang .
THERANOSTICS, 2021, 11 (09) :4298-4315
[4]   RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target [J].
Chen, Huarong ;
Gao, Shanshan ;
Liu, Weixin ;
Wong, Chi-Chun ;
Wu, Jianfeng ;
Wu, Jingtong ;
Liu, Dabin ;
Gou, Hongyan ;
Kang, Wei ;
Zhai, Jianning ;
Li, Chuangen ;
Su, Hao ;
Wang, Shiyan ;
Soares, Fraser ;
Han, Jiahuai ;
He, Housheng Hansen ;
Yu, Jun .
GASTROENTEROLOGY, 2021, 160 (04) :1284-+
[5]   Targeting YTHDF1 effectively re-sensitizes cisplatin-resistant colon cancer cells by modulating GLS-mediated glutamine metabolism [J].
Chen, Ping ;
Liu, Xi-qiao ;
Lin, Xiang ;
Gao, Li-ying ;
Zhang, Shuo ;
Huang, Xuan .
MOLECULAR THERAPY-ONCOLYTICS, 2021, 20 :228-239
[6]   N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis [J].
Chen, Ri-Xin ;
Chen, Xin ;
Xia, Liang-Ping ;
Zhang, Jia-Xing ;
Pan, Zhi-Zhong ;
Ma, Xiao-Dan ;
Han, Kai ;
Chen, Jie-Wei ;
Judde, Jean-Gabrie ;
Deas, Olivier ;
Wang, Feng ;
Ma, Ning-Fang ;
Guan, Xinyuan ;
Yun, Jing-Ping ;
Wang, Feng-Wei ;
Xu, Rui-Hua ;
Xie, Dan .
NATURE COMMUNICATIONS, 2019, 10 (1)
[7]   METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer [J].
Chen, Xiaoxiang ;
Xu, Mu ;
Xu, Xueni ;
Zeng, Kaixuan ;
Liu, Xiangxiang ;
Pan, Bei ;
Li, Chenmeng ;
Sun, Li ;
Qin, Jian ;
Xu, Tao ;
He, Bangshun ;
Pan, Yuqin ;
Sun, Huilin ;
Wang, Shukui .
MOLECULAR CANCER, 2020, 19 (01)
[8]   RETRACTED: METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing (Retracted article. See vol. 30, pg. 2640, 2022) [J].
Chen, Xiaoxiang ;
Xu, Mu ;
Xu, Xueni ;
Zeng, Kaixuan ;
Liu, Xiangxiang ;
Sun, Li ;
Pan, Bei ;
He, Bangshun ;
Pan, Yuqin ;
Sun, Huiling ;
Xia, Xinyi ;
Wang, Shukui .
MOLECULAR THERAPY, 2020, 28 (02) :599-612
[9]   Prognostic Implication of the m6A RNA Methylation Regulators in Rectal Cancer [J].
Chen, Yajie ;
Wang, Shanshan ;
Cho, William C. ;
Zhou, Xiang ;
Zhang, Zhen .
FRONTIERS IN GENETICS, 2021, 12
[10]   m6A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways [J].
Deng, Ru ;
Cheng, Yikan ;
Ye, Shubiao ;
Zhang, Jianwei ;
Huang, Runqing ;
Li, Peisi ;
Liu, Huashan ;
Deng, Qiling ;
Wu, Xianrui ;
Lan, Ping ;
Deng, Yanhong .
ONCOTARGETS AND THERAPY, 2019, 12 :4391-4402
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