Antifungal bioactivity of 6-bromo-4-ethoxyethylthio quinazoline

被引：25

作者：

Liu, Fang ^{[3
]}

Huang, Yinjiu ^{[1
,2
]}

机构：

[1] Bengbu Med Coll, Dept Biosci, Bengbu, Anhui, Peoples R China

[2] Guizhou Univ, Res & Dev Ctr Fine Chem, Guiyang, Guizhou, Peoples R China

[3] Bengbu Med Coll, Dept Pharm, Anhui Engn Technol Res Ctr Biochem Pharmaceut, Bengbu, Anhui, Peoples R China

来源：

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY | 2011年 / 101卷 / 03期

关键词：

6-Bromo-4-ethoxyethylthio quinazoline; Antifungal bioactivity; Mechanism of action; Gibberella zeae; DERIVATIVES; INHIBITOR; GROWTH; POTENT; CHITOSAN; CHITIN; AGENTS;

D O I：

10.1016/j.pestbp.2011.10.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to create novel potent antifungal agents, the antifungal effects of 6-bromo-4-ethoxyethylthio quinazoline on plant pathogenic fungi were evaluated by mycelial growth rate method. The bioassay results showed that title compound possesses high antifungal activities on fungi with EC50 values ranging from 17.47 to 70.79 mu g/mL. The mechanism of action of 6-bromo-4-ethoxyethylthio quinazoline against fungi was studied in Gibberella zeae model. After treated with title compound at 100 mu g/mL for 12 h, the mycelial reducing sugar, chitosan, soluble protein and pyruvate content, chitinase activity showed declining tendency. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：248 / 255

页数：8

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