Perils at mucosal front lines for HIV and SIV and their hosts

被引:339
作者
Haase, AT [1 ]
机构
[1] Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nri1706
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
HIV- 1 and simian immunodeficiency virus ( SIV), as well as their hosts, face perils at mucosal front lines in early infection. At these sites, ' resting' CD4(+) memory T cells fuel infection ( because they are hosts for virus), depleting CD4(+) memory T cells throughout the lymphoid tissues, particularly in the gut, and eliciting an immunosuppressive regulatory T- cell response that impairs host defence. But HIV- 1 and SIV also risk elimination at the earliest stage of infection, at the mucosal point of entry, if founder populations of infected cells do not expand sufficiently to establish a self- propagating infection. Microbicides and vaccines could increase these viral vulnerabilities at mucosal front lines.
引用
收藏
页码:783 / 792
页数:10
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