Formation and insertion of the nitrogenase iron-molybdenum cofactor

被引：146

作者：

Dos Santos, PC

Dean, DR

Hu, YL

Ribbe, MW ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA

[2] Virginia Tech, Dept Biochem, Blacksburg, VA 24061 USA

来源：

CHEMICAL REVIEWS | 2004年 / 104卷 / 02期

关键词：

D O I：

10.1021/cr020608l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The biosynthesis of FeMo-cofactor was described. The metal-sulfur core of FeMo-cofactor was constructed from [4Fe-3S] and [3Fe-Mo-3S] substructures linked by three μ 2-sulfide bridges. The high-resolution crystal structure of the MoFe protein revealed that the central cavity of the FeMo-cofactor contained an interstitial atom. It was also found that the FeMo-cofactor contained homocitrate, an organic constituent, which was attached to the Mo atom through its 2-hydroxy and 2-carboxyl groups.

引用

页码：1159 / 1173

页数：15

共 117 条

[1]

ALLEN RM, 1993, J BIOL CHEM, V268, P23670

[2] INCORPORATION OF IRON AND SULFUR FROM NIFB COFACTOR INTO THE IRON-MOLYBDENUM COFACTOR OF DINITROGENASE [J].