Phosphoinositide-regulated kinases and phosphoinositide phosphatases

被引：94
作者：
Leslie, NR
Biondi, RM
Alessi, DR [1 ]
机构：
[1] Univ Dundee, MRC, Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
[2] Univ Dundee, Dept Life Sci, Div Signal Transduct Therapy, Dundee DD1 5EH, Scotland
来源：
CHEMICAL REVIEWS | 2001年 / 101卷 / 08期
关键词：
D O I：
10.1021/cr000091i
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The mechanism by which protein kinase B (PKB) was activated by 3-phosphoinositide-dependent protein kinase (PDK1) in cells was studied. The activity of the downstream effector pathways activated by phosphoinositides were also discussed. The results showed that all PKB isoforms possessed an N-terminal PH domain followed by a kinase catalytic domain and a C-terminal tail.
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页码：2365 / 2380
页数：16
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