Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1

被引：76
作者：
Li, Lina [1 ,2 ]
Zeng, Zhen [3 ]
Cai, Guoping [1 ,2 ]
机构：
[1] Tsinghua Univ, Dept Biol Sci & Biotechnol, Beijing 10084, Peoples R China
[2] Tsinghua Univ, Div Life Sci, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China
[3] Univ Pittsburgh, Dept Human Genet, Grad Sch Publ Hlth, Pittsburgh, PA 15260 USA
来源：
PHYTOMEDICINE | 2011年 / 18卷 / 11期
关键词：
Naringin; Neoeriocitrin; MC3T3-E1; Osteogenesis; Osteoporosis; BONE; KINASE; CBFA1; GENE;
D O I：
10.1016/j.phymed.2011.03.002
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Naringin is considered the main effective compound of Drynaria Rhizome, which is used commonly in the treatment of osteoporosis in traditional Chinese medicine. However, we found neoeriocitrin, a new compound isolated from Drynaria Rhizome, showed a better activity than naringin on proliferation and osteogenic differentiation in MC3T3-E1. Both neoeriocitrin and naringin exhibited the best effect on proliferation and osteogenic differentiation at concentration of 2 mu g/ml. Neoeriocitrin more significantly improved proliferation and alkaline phosphatase (ALP) activity as well as up-regulated Runx2. COLI and OCN expression by 56%, 37% and 14% respectively than naringin. Furthermore, neoeriocitrin could rescue the inhibition effect of cell differentiation induced by PD98059 to some degree. Therefore, neoeriocitrin may be a new promising candidate drug for treatment of osteoporosis. (C) 2011 Elsevier GmbH. All rights reserved.
引用
收藏
页码：985 / 989
页数：5
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