Synthesis of 2-(5-Aryl-4-methyl-2-oxo-1,2-dihydro-3&ITH&IT-pyrrol-3-ylidene)malononitriles

被引：7
作者：
Belikov, M. Yu. [1 ]
Ievlev, M. Yu. [1 ]
Milovidova, A. G. [1 ]
Ershov, O. V. [1 ]
机构：
[1] Ulyanov Chuvash State Univ, Moskovskii Pr 15, Cheboksary 428015, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 53卷 / 10期
关键词：
4-OXOALKANE-1,1,2,2-TETRACARBONITRILES; DIARYLETHENE; DERIVATIVES; INHIBITORS; ACCEPTOR;
D O I：
10.1134/S1070428017100207
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
4-Oxoalkane-1,1,2,2-tetracarbonitriles in the presence of an equimolar amount of morpholine were converted to previously unknown 2-(5-aryl-4-methyl-2-oxo-1,2-dihydro-3H-pyrrol-3-ylidene)malononitriles.
引用
收藏
页码：1601 / 1603
页数：3
相关论文
共 15 条
[1]   Synthesis and evaluation of some new spiro indoline-based heterocycles as potentially active antimicrobial agents [J].
Abdel-Rahman, AH ;
Keshk, EM ;
Hanna, MA ;
El-Bady, SM .
BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (09) :2483-2488
[2]   Spiro heterocyclization of 4-aryl-4-oxobutane-1,1,2,2-tetracarbonitriles to 3H-pyrrole derivatives, 2-oxa-7-azaspiro[4.4]nona-3,6,8-trienes [J].
Belikov, M. Yu ;
Ershov, O. V. ;
Lipovskaya, I. V. ;
Fedoseev, S. V. ;
Nasakin, O. E. .
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 49 (06) :864-866
[3]   Reaction between 4-oxoalkane-1,1,2,2-tetracarbonitriles and morpholine: regioselective synthesis of 5-amino-2-(morpholin-4-yl)-3-(2-oxoalkyl)-3H-pyrrol-3,4-dicarbonitriles [J].
Belikov, M. Yu. ;
Ershov, O. V. ;
Eremkin, A. V. ;
Nasakin, O. E. ;
Tafeenko, V. A. ;
Nurieva, E. V. .
TETRAHEDRON LETTERS, 2011, 52 (48) :6407-6410
[4]   Rearrangement of 4-oxobutane-1,1,2,2-tetracarbonitriles to the penta-1,3-diene-1,1,3-tricarbonitrile moiety as an approach to novel acceptors for donor-acceptor chromophores [J].
Belikov, Mikhail Yu. ;
Fedoseev, Sergey V. ;
Ershov, Oleg V. ;
Ievlev, Mikhail Yu. ;
Tafeenko, Viktor A. .
TETRAHEDRON LETTERS, 2016, 57 (36) :4101-4104
[5]   Directed synthesis of new spiro-fused photochromes of diarylethene series [J].
Belikov, Mikhail Yu. ;
Ievlev, Mikhail Yu. ;
Belikova, Irina V. ;
Ershov, Oleg V. ;
Tafeenko, Viktor A. ;
Surazhskaya, Marina D. .
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2015, 51 (06) :518-525
[6]   Interaction of 4-oxoalkane-1,1,2,2-tetracarbonitriles with Lawesson's reagent a new approach to the synthesis of 2,2′-disulfanediylbis(1H-pyrroles). The synthesis of photochromic diarylethene with a disulfide bridge [J].
Belikov, Mikhail Yu. ;
Fedoseev, Sergey V. ;
Ievlev, Mikhail Yu. ;
Ershov, Oleg V. ;
Tafeenko, Victor A. .
RSC ADVANCES, 2015, 5 (80) :65316-65320
[7]   Isatin sulfonamide analogs containing a michael addition acceptor: A new class of caspase 3/7 inhibitors [J].
Chu, Wenhua ;
Rothfuss, Justin ;
d'Avignon, Andre ;
Zeng, Chenbo ;
Zhou, Dong ;
Hotchkiss, Richard S. ;
Mach, Robert H. .
JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (15) :3751-3755
[8]   Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: Introduction of a hydrophilic group increases potency in a whole cell assay [J].
Chu, Wenhua ;
Rothfuss, Justin ;
Zhou, Dong ;
Mach, Robert H. .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (08) :2192-2197
[9]   Three-component spiro heterocyclization of pyrrole-2,3-diones with malononitrile and indan-1,3-dione [J].
Dmitriev, M. V. ;
Silaichev, P. S. ;
Maslivets, A. N. .
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 52 (04) :600-601
[10]   Domino synthesis of 3-amino-8-hydroxy-1,6-dioxo-2,7-diazaspiro[4.4]non-3-ene-4-carbonitriles [J].
Fedoseev, Sergey V. ;
Ershov, Oleg V. ;
Belikov, Mikhail Yu ;
Lipin, Konstantin V. ;
Bardasov, Ivan N. ;
Nasakin, Oleg E. ;
Tafeenko, Viktor A. .
TETRAHEDRON LETTERS, 2013, 54 (17) :2143-2145
12