Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons

被引：172

作者：

McKay, LC ^{[1
]}

Janczewski, WA ^{[1
]}

Feldman, JL ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 09期

关键词：

D O I：

10.1038/nn1517

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ablation of preBotzinger complex (preBotC) neurons, critical for respiratory rhythm generation, resulted in a progressive, increasingly severe disruption of respiratory pattern, initially during sleep and then also during wakefulness in adult rats. Sleep-disordered breathing is highly prevalent in elderly humans and in some patients with neurodegenerative disease. We propose that sleep-disordered breathing results from loss of preBotC neurons and could underlie death during sleep in these populations.

引用

页码：1142 / 1144

页数：3

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