Synthesis of a Maleimide-Diaminoterephthalate Fluorescence Dye as a 'Turn-On' Probe for the Detection of Thiols

被引：3
|
作者：
Schroeder, Nils [1 ]
Christoffers, Jens [1 ]
机构：
[1] Carl von Ossietzky Univ Oldenburg, Inst Chem, D-26111 Oldenburg, Germany
来源：
SYNTHESIS-STUTTGART | 2022年 / 54卷 / 10期
关键词：
diaminoterephthalate; dye; fluorescence; glutathione; maleimide; thiol; turn-on probe; QUANTUM YIELDS; FLUOROPHORES; ACID; BIOCONJUGATION; CYSTEINE;
D O I：
10.1055/s-0040-1719889
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A fluorescence 'turn-on' probe for the detection of thiols was prepared in three steps. A diaminoterephthalate chromophore (λabs= 472 nm) was equipped with a maleimide moiety as reactive group. Upon conjugate addition of the thiol, the fluorescence intensity is increased by a factor of about twenty (λem= 567 nm, quantum yield φ = 1% → 14%). The probe is used to establish a quantitative assay for glutathione. © 2022 EDP Sciences. All rights reserved.
引用
收藏
页码：2511 / 2515
页数：5
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