Glutamic acid as an efficient and green catalyst for the one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles under thermal, solvent-free conditions

被引：23

作者：

Feizabad, Fahimeh Khazaee ^{[1
]}

Khandan-Barani, Khatereh ^{[1
]}

Hassanabadi, Alireza ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Zahedan Branch, POB 98135-978, Zahedan, Iran

来源：

JOURNAL OF CHEMICAL RESEARCH | 2017年 / 41卷 / 11期

关键词：

glutamic acid; 1,2,4,5-tetrasubstituted imidazoles; solvent-free; green catalyst; ammonium acetate; 1,2-dicarbonyl compounds; TETRASUBSTITUTED IMIDAZOLES; COMPONENT REACTIONS;

D O I：

10.3184/174751917X15105690662854

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A high-yielding synthesis of 1,2,4,5-tetrasubstituted imidazoles is described, involving the reaction of 1,2-dicarbonyl compounds, aryl aldehydes, amines and ammonium acetate in the presence of a catalytic amount of glutamic acid under thermal, solvent-free conditions. The salient features of this protocol are aerobic conditions, a non-hazardous green catalyst, short reaction times and mild reaction conditions.

引用

页码：673 / 675

页数：3

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