Synthesis of furo[3,2-b]pyridine analogue of efaroxan

被引：4

作者：

Mayer, P ^{[1
]}

Loubat, C ^{[1
]}

Imbert, T ^{[1
]}

机构：

[1] Ctr Rech Pierre Fabre, Div Med Chem, F-81100 Castres, France

来源：

HETEROCYCLES | 1998年 / 48卷 / 12期

关键词：

D O I：

10.3987/COM-98-8307

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-(4,5 -Dihydro-1H-imidazol-2-yl)-2-ethyl-2,3 -dihydrofuro[3,2-b]pyridine was synthesized in eight steps starting from 3-hydroxy-2-methylpyridine. The key step was a cyclization of a 2-chloromethyl-3-butyroxypyridine derivative. The target molecule is an aza analogue of efaroxan, a potent and selective antagonist of a 2-adrenoceptors.

引用

页码：2529 / 2534

页数：6

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