Inherited IgA glycosylation pattern in IgA nephropathy and HSP nephritis: where do we go next?

被引：11

作者：

Boyd, Joanna K. ^{[2
]}

Barratt, Jonathan ^{[1
,2
]}

机构：

[1] Leicester Gen Hosp, Dept Infect Immun & Inflammat, John Walls Renal Unit, Leicester LE5 4PW, Leics, England

[2] Univ Leicester, Dept Infect Immun & Inflammat, Leicester, Leics, England

来源：

KIDNEY INTERNATIONAL | 2011年 / 80卷 / 01期

关键词：

O-GLYCOSYLATION; COSMC;

D O I：

10.1038/ki.2011.83

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

New data from Kiryluk et al. show the importance of genetic factors in determining the profile of serum IgA1 O-glycoforms in IgA nephropathy and Henoch-Schonlein purpura nephritis. Elevated serum levels of poorly galactosylated IgA1 O-glycoforms do not, however, appear sufficient in themselves to cause nephritis in these two diseases, and a 'second hit' is necessary before changes in IgA1 glycosylation translate into clinical disease. The challenge now is to determine what these genetic factors are.

引用

页码：8 / 10

页数：3

共 10 条

[1] Abnormal IgA glycosylation in Henoch-Schonlein purpura restricted to patients with clinical nephritis [J].

Allen, AC ;

Willis, FR ;

Beattie, TJ ;

Feehally, J .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 1998, 13 (04) :930-934

[2] What is the difference between IgA nephropathy and Henoch-Schonlein purpura nephritis? [J].

Davin, JC ;

ten Berge, IJ ;

Weening, JJ .

KIDNEY INTERNATIONAL, 2001, 59 (03) :823-834

[3] Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy [J].

Gharavi, Ali G. ;

Moldoveanu, Zina ;

Wyatt, Robert J. ;

Barker, Catherine V. ;

Woodford, Susan Y. ;

Lifton, Richard P. ;

Mestecky, Jiri ;

Novak, Jan ;

Julian, Bruce A. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 19 (05) :1008-1014

[4] Galactose-Deficient IgA1 in African Americans with IgA Nephropathy: Serum Levels and Heritability [J].

Hastings, M. Colleen ;

Moldoveanu, Zina ;

Julian, Bruce A. ;

Novak, Jan ;

Sanders, John T. ;

McGlothan, Kim R. ;

Gharavi, Ali G. ;

Wyatt, Robert J. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2010, 5 (11) :2069-2074

[5] Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch-Schonlein purpura nephritis [J].

Kiryluk, Krzysztof ;

Moldoveanu, Zina ;

Sanders, John T. ;

Eison, T. Matthew ;

Suzuki, Hitoshi ;

Julian, Bruce A. ;

Novak, Jan ;

Gharavi, Ali G. ;

Wyatt, Robert J. .

KIDNEY INTERNATIONAL, 2011, 80 (01) :79-87

[6] Aberrant galactosylation of IgA1 is involved in the genetic susceptibility of Chinese patients with IgA nephropathy [J].

Lin, Xiaojie ;

Ding, Jiaxiang ;

Zhu, Li ;

Shi, Sufang ;

Jiang, Lei ;

Zhao, Minghui ;

Zhang, Hong .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2009, 24 (11) :3372-3375

[7] External suppression causes the low expression of the Cosmc gene in IgA nephropathy [J].

Qin, Wei ;

Zhong, Xiang ;

Fan, Jun Ming ;

Zhang, Ying Juan ;

Liu, Xian Rong ;

Ma, Xing Yi .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2008, 23 (05) :1608-1614

[8] O-glycosylation of serum IgA1 antibodies against mucosal and systemic antigens in IgA nephropathy [J].

Smith, Alice C. ;

Molyneux, Karen ;

Feehally, John ;

Barratt, Jonathan .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (12) :3520-3528

[9] Toll-Like Receptor 9 Affects Severity of IgA Nephropathy [J].

Suzuki, Hitoshi ;

Suzuki, Yusuke ;

Narita, Ichiei ;

Aizawa, Masashi ;

Kihara, Masao ;

Yamanaka, Takahiro ;

Kanou, Tatsuya ;

Tsukaguchi, Hiroyasu ;

Novak, Jan ;

Horikoshi, Satoshi ;

Tomino, Yasuhiko .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 19 (12) :2384-2395

[10] Down-regulation of core 1 β1,3-galactosyltransferase and Cosmc by Th2 cytokine alters O-glycosylation of IgA1 [J].

Yamada, Koshi ;

Kobayashi, Noriyoshi ;

Ikeda, Tomomi ;

Suzuki, Yusuke ;

Tsuge, Toshinao ;

Horikoshi, Satoshi ;

Emancipator, Steven N. ;

Tomino, Yasuhiko .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2010, 25 (12) :3890-3897

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