Cyclin D1 and breast cancer

被引：189
作者：
Roy, Pankaj G. [1 ]
Thompson, Alastair M. [1 ]
机构：
[1] Univ Dundee, Ninewells Hosp & Med Sch, Dept Surg & Mol Oncol, Dundee DD1 9SY, Scotland
来源：
BREAST | 2006年 / 15卷 / 06期
关键词：
cyclin D1; oestrogen; breast cancer; immunohistochemistry; gene amplification;
D O I：
10.1016/j.breast.2006.02.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cyclin D1 is one of the frequently overexpressed proteins and one of the commonly amplified genes in breast cancer. This article reviews the roles of cyctin D1 in cell-cycle regulation (normal and abnormal), mammary gland development and carcinogenesis and the relationship to oestrogen in breast tissues. It concludes by presenting the clinical, prognostic and therapeutic implications of our current knowledge of cyclin D1 in breast cancer. (c) 2006 Elsevier Ltd. All rights reserved.
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收藏
页码：718 / 727
页数：10
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