Hepatitis C Virus Assembly Imaging

被引：15
作者：
Popescu, Costin-Ioan [1 ]
Rouille, Yves [2 ]
Dubuisson, Jean [2 ]
机构：
[1] Romanian Acad, Inst Biochem, Bucharest 060031 17, Romania
[2] Univ Lille Nord France, Inserm U1019, CNRS UMR8204, CIIL,Inst Pasteur Lille, F-59021 Lille, France
来源：
VIRUSES-BASEL | 2011年 / 3卷 / 11期
关键词：
hepatitis C virus; virus assembly; cellular imaging; NONSTRUCTURAL PROTEIN 5A; CORE PROTEIN; LIPID DROPLET; ENDOPLASMIC-RETICULUM; RNA REPLICATION; CELLULAR DETERMINANTS; TRANSMEMBRANE DOMAIN; APOLIPOPROTEIN-E; BINDING DOMAIN; NS5A PROTEIN;
D O I：
10.3390/v3112238
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Hepatitis C Virus (HCV) assembly process is the least understood step in the virus life cycle. The functional data revealed by forward and reverse genetics indicated that both structural and non-structural proteins are involved in the assembly process. Using confocal and electron microscopy different groups determined the subcellular localization of different viral proteins and they identified the lipid droplets (LDs) as the potential viral assembly site. Here, we aim to review the mechanisms that govern the viral proteins recruitment to LDs and discuss the current model of HCV assembly process. Based on previous examples, this review will also discuss advanced imaging techniques as potential means to extend our present knowledge of HCV assembly process.
引用
收藏
页码：2238 / 2254
页数：17
相关论文
共 83 条
[1]   Characterization of low- and very-low-density hepatitis C virus RNA-containing particles [J].
André, P ;
Komurian-Pradel, F ;
Deforges, S ;
Perret, M ;
Berland, JL ;
Sodoyer, M ;
Pol, S ;
Bréchot, C ;
Paranhos-Baccalà, G ;
Lotteau, V .
JOURNAL OF VIROLOGY, 2002, 76 (14) :6919-6928
[2]   Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly [J].
Appel, Nicole ;
Zayas, Margarita ;
Miller, Sven ;
Krijnse-Locker, Jacomine ;
Schaller, Torsten ;
Friebe, Peter ;
Kallis, Stephanie ;
Engel, Ulrike ;
Bartenschlager, Ralf .
PLOS PATHOGENS, 2008, 4 (03)
[3]   Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets [J].
Barba, G ;
Harper, F ;
Harada, T ;
Kohara, M ;
Goulinet, S ;
Matsuura, Y ;
Eder, G ;
Schaff, Z ;
Chapman, MJ ;
Miyamura, T ;
Brechot, C .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (04) :1200-1205
[4]   Assembly of infectious hepatitis C virus particles [J].
Bartenschlager, Ralf ;
Penin, Francois ;
Lohmann, Volker ;
Andre, Patrice .
TRENDS IN MICROBIOLOGY, 2011, 19 (02) :95-103
[5]   Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes [J].
Bartosch, B ;
Dubuisson, J ;
Cosset, FL .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (05) :633-642
[6]   A Concerted Action of Hepatitis C Virus P7 and Nonstructural Protein 2 Regulates Core Localization at the Endoplasmic Reticulum and Virus Assembly [J].
Boson, Bertrand ;
Granio, Ophelia ;
Bartenschlager, Ralf ;
Cosset, Francois-Loic .
PLOS PATHOGENS, 2011, 7 (07)
[7]   Hepatitis C virus core protein is a dimeric alpha-helical protein exhibiting membrane protein features [J].
Boulant, S ;
Vanbelle, C ;
Ebel, C ;
Penin, F ;
Lavergne, JP .
JOURNAL OF VIROLOGY, 2005, 79 (17) :11353-11365
[8]   Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner [J].
Boulant, Steeve ;
Douglas, Mark W. ;
Moody, Laura ;
Budkowska, Agata ;
Targett-Adams, Paul ;
McLauchlan, John .
TRAFFIC, 2008, 9 (08) :1268-1282
[9]   Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus [J].
Boulant, Steeve ;
Targett-Adams, Paul ;
McLauchlan, John .
JOURNAL OF GENERAL VIROLOGY, 2007, 88 :2204-2213
[10]   Structural determinants that target the hepatitis C virus core protein to lipid droplets [J].
Boulant, Steeve ;
Montserret, Roland ;
Hope, R. Graham ;
Ratinier, Maxime ;
Targett-Adams, Paul ;
Lavergne, Jean-Pierre ;
Penin, Francois ;
McLauchlan, John .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (31) :22236-22247
123456789