Indocyanine-Based Activatable Fluorescence Turn-On Probe for γ-Glutamyltranspeptidase and Its Application to the Mouse Model of Colon Cancer

被引：49

作者：

Park, Seokan ^{[1
]}

Lim, Soo-Yeon ^{[1
]}

Bae, Sang Mun ^{[2
,4
]}

Kim, Sang-Yeob ^{[2
,4
]}

Myung, Seung-Jae ^{[2
,3
]}

Kim, Hae-Jo ^{[1
]}

机构：

[1] Hankuk Univ Foreign Studies, Dept Chem, Yongin 449791, South Korea

[2] Univ Ulsan, Coll Med, Asan Inst Life Sci, Seoul 138736, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul 138736, South Korea

[4] Univ Ulsan, Coll Med, Dept Med, Seoul 138736, South Korea

来源：

ACS SENSORS | 2016年 / 1卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

activatable fluorescent probe; colon cancer; cyanine dye; gamma-glutamyltranspeptidase; TRANSFERASE; INHIBITOR; GGSTOP;

D O I：

10.1021/acssensors.5b00249

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An activatable fluorescent probe from indocyanine was developed for the detection of tumor-enriched gamma-glutamyltranspeptidase (gamma GT). The probe exhibited a dramatic fluorescence enhancement (F/F-0 = 10) as well as a bathochromic shift (>100 nm) upon the treatment of gamma GT with a low limit of detection of 0.15 unit/L and was further successfully applied as a sensitive probe for gamma GT in the mouse model of colon cancer.

引用

页码：579 / 583

页数：5

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