The role of respiratory control disorders in SIDS

被引:74
作者
Thach, BT [1 ]
机构
[1] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA
关键词
SIDS; apnea of prematurity; obstructed sleep apnea;
D O I
10.1016/j.resp.2005.06.011
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Although sudden death in infants resulting from cardiac arrhythmias are well documented these appear to account for no more than 5-10% of SIDS cases. Sudden respiratory failure currently is viewed as the most likely cause of death in the remainder. Accidental asphyxiation appears to have a causal role in less then 50% of deaths diagnosed as SIDS. The rest are most likely do to some form of acute respiratory failure. Although failure of autoresuscitation or failure to arouse from sleep likely contribute to the final sequence of events leading to at least some SIDS deaths, these cannot be regarded as causes of the primary respiratory failure initiating the fatal sequence. Past and current studies provide strong circumstantial evidence that obstructive sleep apnea and/or apnea of prematurity likely account for respiratory failure leading to SIDS in some or many deaths. In drawing conclusions it is well to recognize that mechanisms leading to death in SIDS are heterogeneous and therefore there is room for several plausible theories for respiratory or circulatory abnormalities contributing to SIDS. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:343 / 353
页数:11
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