The post-treatment neutrophil-to-lymphocyte ratio and changes in this ratio predict survival after treatment of stage III non-small-cell lung cancer with conventionally fractionated radiotherapy

被引：13

作者：

Wang, Duoying ^{[1
,2
]}

Guo, Dong ^{[3
]}

Li, Aijie ^{[1
,2
]}

Wang, Peiliang ^{[2
]}

Teng, Feifei ^{[2
]}

Yu, Jinming ^{[2
]}

机构：

[1] Weifang Med Univ, Dept Clin Med, Weifang, Peoples R China

[2] Shandong First Med Univ & Shandong Acad Med Sci, Dept Radiotherapy, Shandong Canc Hosp & Inst, Jinan, Peoples R China

[3] Sunshine Union Hosp, Dept Radiotherapy, Weifang, Peoples R China

来源：

FUTURE ONCOLOGY | 2020年 / 16卷 / 09期

关键词：

changes in neutrophil-to-lymphocyte ratio; non-small-cell lung cancer; prognosis; radiotherapy; survival; TREATMENT-RELATED LYMPHOPENIA; PROGNOSTIC VALUE; COMPLETE RESECTION; RADIATION; ASSOCIATION; CHEMOTHERAPY; INFLAMMATION; MECHANISMS; BIOMARKER;

D O I：

10.2217/fon-2019-0837

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To investigate the predictive potential of post-treatment neutrophil-to-lymphocyte ratio (NLR) and changes in this ratio (Delta NLR) for stage III non-small-cell lung cancer (NSCLC) patients who received conventionally fractionated radiotherapy (CFRT). Patients & methods: The data of 168 NSCLC patients treated at the Shandong Cancer Hospital were analyzed retrospectively. The relationship between progression-free survival (PFS), overall survival (OS) and post-treatment NLR and Delta NLR were analyzed using both Kaplan-Meier and Cox regression methods. Results: Kaplan-Meier survival analyses showed that post-treatment NLR and Delta NLR were associated with PFS (p < 0.001) and OS (p < 0.001) after CFRT. Multivariate analyses revealed that Delta NLR was an independent predictor of PFS (p = 0.001) and OS (p = 0.018). Post-treatment NLR can only be used as an independent predictor of PFS (p = 0.040). Conclusion: Our results demonstrated the prognostic value of the Delta NLR in predicting PFS and OS in stage III NSCLC patients undergoing CFRT. However, post-treatment NLR has predictive value only for PFS.

引用

页码：439 / 449

页数：11

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