SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinations

被引：23

作者：

Anderson, Elizabeth M. ^{[1
]}

Li, Shuk Hang ^{[1
]}

Awofolaju, Moses ^{[1
]}

Eilola, Theresa ^{[1
]}

Goodwin, Eileen ^{[1
]}

Bolton, Marcus J. ^{[1
]}

Gouma, Sigrid ^{[1
]}

Manzoni, Tomaz B. ^{[1
]}

Hicks, Philip ^{[1
]}

Goel, Rishi R. ^{[2
,3
,4
]}

Painter, Mark M. ^{[2
,3
,4
]}

Apostolidis, Sokratis A. ^{[2
,3
,5
]}

Mathew, Divij ^{[2
,3
,4
]}

Dunbar, Debora ^{[6
]}

Fiore, Danielle ^{[7
]}

Brock, Amanda ^{[8
]}

Weaver, JoEllen ^{[8
]}

Millar, John S. ^{[9
]}

DerOhannessian, Stephanie ^{[8
,9
]}

Greenplate, Allison R. ^{[2
,3
]}

Frank, Ian

Rader, Daniel J. ^{[9
]}

Wherry, E. John ^{[2
,3
,4
,10
]}

Bates, Paul ^{[1
]}

Hensley, Scott E. ^{[1
,2
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Inst Immunol, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Perelman Sch Med, Immune Hlth, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Syst Pharmacol & Translat Therapeut, Philadelphia, PA 19104 USA

[5] Univ Penn, Perelman Sch Med, Div Rheumatol, Philadelphia, PA 19104 USA

[6] Univ Penn, Perelman Sch Med, Div Infect Dis, Philadelphia, PA 19104 USA

[7] Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA

[8] Univ Penn, Inst Translat Med & Therapeut, Perelman Sch Med, Philadelphia, PA 19104 USA

[9] Univ Penn, Perelman Sch Med, Dept Genet & Med, Philadelphia, PA 19104 USA

[10] Univ Penn, Parker Inst Canc Immunotherapy, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

CELL REPORTS | 2022年 / 41卷 / 03期

基金：

美国国家卫生研究院;

关键词：

SPIKE; IMMUNITY; OC43; NL63;

D O I：

10.1016/j.celrep.2022.111496

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It is important to determine if severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and SARS-CoV-2 mRNA vaccinations elicit different types of antibodies. Here, we characterize the magnitude and specificity of SARS-CoV-2 spike-reactive antibodies from 10 acutely infected health care workers with no prior SARS-CoV-2 exposure history and 23 participants who received SARS-CoV-2 mRNA vaccines. We found that infection and primary mRNA vaccination elicit S1-and S2-reactive antibodies, while secondary vaccination boosts mostly S1 antibodies. Using absorption assays, we found that SARS-CoV-2 infections elicit a large proportion of original antigenic sin-like antibodies that bind efficiently to the spike of common seasonal human coronaviruses but poorly to the spike of SARS-CoV-2. In converse, vaccination modestly boosts antibodies reactive to the spike of common seasonal human coronaviruses, and these antibodies cross-react more efficiently to the spike of SARS-CoV-2. Our data indicate that SARS-CoV-2 infections and mRNA vaccinations elicit fundamentally different antibody responses.

引用

页数：15

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