Growth hormone treatment in cartilage-hair hypoplasia: Effects on growth and the immune system

被引：0
作者：
Bocca, G
Weemaes, CM
van der Burgt, I
Otten, BJ
机构：
[1] Univ Med Ctr St Radboud, Dept Pediat Endocrinol, NL-6500 HB Nijmegen, Netherlands
[2] Univ Med Ctr St Radboud, Dept Pediat, NL-6500 HB Nijmegen, Netherlands
[3] Univ Med Ctr St Radboud, Dept Pediat Immunol, NL-6500 HB Nijmegen, Netherlands
[4] Univ Med Ctr St Radboud, Dept Human Genet, NL-6500 HB Nijmegen, Netherlands
[5] Univ Med Ctr St Radboud, Dept Pediat Endocrinol, NL-6500 HB Nijmegen, Netherlands
来源：
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2004年 / 17卷 / 01期
关键词：
cartilage-hair hypoplasia; growth hormone; immune function;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cartilage-hair hypoplasia (CHH) is a rare autosomal recessive disorder characterized by metaphyseal chondrodysplasia with severe growth retardation and impaired immunity. We studied the effects of growth hormone treatment on growth parameters and the immune system in four children with CHH. The effects of growth hormone on growth parameters are the most prominent in patients with the mildest growth retardation. However, the effects are temporary and last only for 1 year. There is no gain in final height. Serum immunoglobulins did not change during growth hormone treatment. We conclude that growth hormone treatment is not beneficial in children with CHH.
引用
收藏
页码：47 / 54
页数：8
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