COVID-19 Hospitalization in Adults with Type 1 Diabetes: Results from the T1D Exchange Multicenter Surveillance Study

被引:27
作者
O'Malley, Grenye [1 ]
Ebekozien, Osagie [2 ]
Desimone, Marisa [3 ]
Pinnaro, Catherina T. [4 ]
Roberts, Alissa [5 ]
Polsky, Sarit [6 ]
Noor, Nudrat [2 ]
Aleppo, Grazia [7 ]
Basina, Marina [8 ]
Tansey, Michael [4 ]
Steenkamp, Devin [9 ,10 ]
Vendrame, Francesco [11 ]
Lorincz, Ilona [12 ]
Mathias, Priyanka [13 ]
Agarwal, Shivani [13 ]
Golden, Lauren [14 ]
Hirsch, Irl B. [15 ]
Levy, Carol J. [1 ]
机构
[1] Icahn Sch Med, Dept Endocrinol Diabet & Bone Dis, New York, NY 10029 USA
[2] T1D Exchange, Boston, MA 02111 USA
[3] SUNY Upstate Med Univ, Div Endocrinol Diabet & Metab, Syracuse, NY 13210 USA
[4] Univ Iowa, Stead Family Dept Pediat, Iowa City, IA 52242 USA
[5] Univ Washington, Dept Pediat, Seattle, WA 98195 USA
[6] Univ Colorado, Barbara Davis Ctr Diabet, Anschutz Med Campus, Aurora, CO 80045 USA
[7] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
[8] Stanford Univ, Sch Med, Stanford, CA 94305 USA
[9] Boston Univ, Sch Med, Boston, MA 02118 USA
[10] Boston Med Ctr, Boston, MA 02118 USA
[11] Univ Miami, Div Endocrinol Diabet & Metab, Miami, FL 33136 USA
[12] Hosp Univ Penn, Dept Endocrinol Diabet & Metab, 3400 Spruce St, Philadelphia, PA 19104 USA
[13] Albert Einstein Coll Med, Fleischer Inst Diabet & Metab, NY Reg Ctr Diabet & Translat Res, New York, NY 10461 USA
[14] NYU, Langone Med Ctr, New York, NY 10016 USA
[15] Univ Washington, Sch Med, Seattle, WA 98195 USA
关键词
type; 1; diabetes; adult; hospitalization; COVID-19; MORTALITY;
D O I
10.1210/clinem/dgaa825
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context Diabetes mellitus is associated with increased COVID-19 morbidity and mortality, but there are few data focusing on outcomes in people with type 1 diabetes. Objective The objective of this study was to analyze characteristics of adults with type 1 diabetes for associations with COVID-19 hospitalization. Design An observational multisite cross-sectional study was performed. Diabetes care providers answered a 33-item questionnaire regarding demographics, symptoms, and diabetes- and COVID-19-related care and outcomes. Descriptive statistics were used to describe the study population, and multivariate logistic regression models were used to analyze the relationship between glycated hemoglobin (HbA1c), age, and comorbidities and hospitalization. Setting Cases were submitted from 52 US sites between March and August 2020. Patients or Other Participants Adults over the age of 19 with type 1 diabetes and confirmed COVID-19 infection were included. Interventions None. Main Outcome Measures Hospitalization for COVID-19 infection. Results A total of 113 cases were analyzed. Fifty-eight patients were hospitalized, and 5 patients died. Patients who were hospitalized were more likely to be older, to identify as non-Hispanic Black, to use public insurance, or to have hypertension, and less likely to use continuous glucose monitoring or insulin pumps. Median HbA1c was 8.6% (70 mmol/mol) and was positively associated with hospitalization (odds ratio 1.42, 95% confidence interval 1.18-1.76), which persisted after adjustment for age, sex, race, and obesity. Conclusions Baseline glycemic control and access to care are important modifiable risk factors which need to be addressed to optimize care of people with type 1 diabetes during the worldwide COVID-19 pandemic.
引用
收藏
页码:E936 / E942
页数:7
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