Diffusion-weighted imaging reflects variable cellularity and stromal density present in breast fibroadenomas

被引：21

作者：

Parsian, Sana ^{[1
]}

Giannakopoulos, Nadia V. ^{[2
,4
]}

Rahbar, Habib ^{[1
]}

Rendi, Mara H. ^{[2
]}

Chai, Xiaoyu ^{[3
]}

Partridge, Savannah C. ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Seattle Canc Care Alliance, Dept Radiol, 825 Eastlake Ave E,G3-200, Seattle, WA 98109 USA

[2] Univ Washington, Sch Med, Dept Anat Pathol, 1959 NE Pacific St,Box 356100, Seattle, WA 98195 USA

[3] Fred Hutchinson Canc Res Ctr, Dept Biostat & Biomath, 1100 Fairview Ave N,M2-B500, Seattle, WA 98109 USA

[4] Univ Alberta, Dept Lab Med & Pathol, 564-57 WMC,8440 112 ST NW, Edmonton, AB T6G 2B7, Canada

来源：

CLINICAL IMAGING | 2016年 / 40卷 / 05期

关键词：

Fibroadenomas; Diffusion-weighted imaging (DWI); Apparent diffusion coefficient (ADC); Cellularity; Stroma; T2-WEIGHTED MR-IMAGES; HIGH-SIGNAL INTENSITY; DIFFERENTIAL-DIAGNOSIS; LESIONS; CANCER; WOMEN; MAMMOGRAPHY; SEQUENCES; CONTRAST; BENIGN;

D O I：

10.1016/j.clinimag.2016.06.002

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Objective: To determine the underlying histopathologic features influencing apparent diffusion coefficient (ADC) values of breast fibroadenomas. Materials and Methods: Biopsy-proven fibroadenomas (n=26) initially identified as suspicious on breast magnetic resonance imaging (MRI) were retrospectively evaluated. Histopathologic assessments of lesion cellularity and stromal type were compared with ADC measures on diffusion-weighted MRI. Results: Presence of epithelial hyperplasia (increased cellularity) and dense collagenous stroma were both significantly associated with lower lesion ADC values (P=.02 and .004, respectively). Conclusion: Variations in epithelial cellularity and stromal type influence breast lesion ADC values and may explain the wide range of ADC measures observed in benign fibroadenomas. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：1047 / 1054

页数：8

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