Abnormally activated signaling pathways as potential therapeutic targets, and diagnostic biomarkers in the management of small-cell lung cancers - A review

被引：0

作者：

Zhang, Lihai ^{[1
]}

Dai, Longxia ^{[1
]}

Xiao, Jian ^{[1
]}

He, Bixiu ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Elderly Resp, Changsha 410008, Peoples R China

来源：

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH | 2021年 / 20卷 / 12期

关键词：

Small cell lung cancer (SCLC); Signaling pathway; Biomarker; Lung cancer; Chemotherapy; Radiotherapy; Immunotherapy;

D O I：

10.4314/tjpr.v20i12.30

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Small-cell lung cancer (SCLC) has relatively aggressive spread characteristics and a poor prognosis. Current treatment methods include surgery, chemotherapy, radiotherapy, and immunotherapy. However, the prognosis remains poor. This article summarizes the related signaling pathways and factors that may be used as therapeutic targets and early diagnostic biomarkers in the pathogenesis of SCLC. Furthermore, this study provides a theoretical reference for the clinical treatment of SCLC.

引用

页码：2675 / 2679

页数：5

共 49 条

[1] A narrative review of current and potential prognostic biomarkers for immunotherapy in small-cell lung cancer [J].

Lim, Jeong Uk ;

Kang, Hye Seon .

ANNALS OF TRANSLATIONAL MEDICINE, 2021, 9 (09)

[2] Small-cell lung cancer. Diagnostic and therapeutic recommendations of Polish Lung Cancer Group [J].

Krzakowski, Maciej ;

Orlowski, Tadeusz ;

Roszkowski, Kazimierz ;

Reinfuss, Marian ;

Olszewski, Wlodzimierz ;

Ramlau, Rodryg ;

Kowalski, Dariusz ;

Konopa, Krzysztof ;

Jassem, Jacek ;

Jankowska, Renata ;

Kozielski, Jerzy ;

Wojtukiewicz, Marek ;

Drosik, Kazimierz ;

Koralewski, Piotr .

ONCOLOGY IN CLINICAL PRACTICE, 2007, 3 (01) :1-7

[3] Lung Cancer Stem Cell Markers as Therapeutic Targets: An Update on Signaling Pathways and Therapies [J].

Zheng, Yue ;

Wang, Laduona ;

Yin, Limei ;

Yao, Zhuoran ;

Tong, Ruizhan ;

Xue, Jianxin ;

Lu, You .

FRONTIERS IN ONCOLOGY, 2022, 12

[4] Diagnostic, Predictive, and Prognostic Biomarkers in Non-Small Cell Lung Cancer (NSCLC) Management [J].

Sutic, Maja ;

Vukic, Ana ;

Baranasic, Jurica ;

Foersti, Asta ;

Dzubur, Feda ;

Samarzija, Miroslav ;

Jakopovic, Marko ;

Brcic, Luka ;

Knezevic, Jelena .

JOURNAL OF PERSONALIZED MEDICINE, 2021, 11 (11)

[5] Circulating endothelial cells and microparticles as diagnostic and prognostic biomarkers in small-cell lung cancer [J].

Najjar, Fadi ;

Alammar, Moosheer ;

Al-Massarani, Ghassan ;

Almalla, Nissreen ;

Japawe, Abdulmunim ;

Ikhtiar, Adnan .

LUNG CANCER, 2018, 124 :23-30

[6] Renal Cell Carcinoma as a Metabolic Disease: An Update on Main Pathways, Potential Biomarkers, and Therapeutic Targets [J].

di Meo, Nicola Antonio ;

Lasorsa, Francesco ;

Rutigliano, Monica ;

Loizzo, Davide ;

Ferro, Matteo ;

Stella, Alessandro ;

Bizzoca, Cinzia ;

Vincenti, Leonardo ;

Pandolfo, Savio Domenico ;

Autorino, Riccardo ;

Crocetto, Felice ;

Montanari, Emanuele ;

Spilotros, Marco ;

Battaglia, Michele ;

Ditonno, Pasquale ;

Lucarelli, Giuseppe .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (22)

[7] Non-coding RNAs and Hippo signaling in non-small cell lung cancer: emerging roles as biomarkers and therapeutic targets [J].

Joulani, Mohammadamin ;

Aghajamal, Nahal ;

Nouri, Masoumeh ;

Khajeh, Faraz Rahmani ;

Sharifi, Nafiseh ;

Saghafi, Dena ;

Amiri, Mahan ;

Abdollahzadeh, Ali ;

Heidari, Ehsan ;

Mirdamadian, Amin ;

Sharafi, Malihe ;

Masoumi, Samira ;

Morovatshoar, Reza ;

Azani, Alireza ;

Behfar, Qumars .

DISCOVER ONCOLOGY, 2025, 16 (01)

[8] Long non-coding RNAs as potential therapeutic targets in non-small cell lung cancer (Review) [J].

Tang, Peiyu ;

Sun, Dejuan ;

Xu, Wei ;

Li, Hua ;

Chen, Lixia .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2023, 52 (02)

[9] Hippo pathway in non-small cell lung cancer: mechanisms, potential targets, and biomarkers [J].

Liang, Hongge ;

Xu, Yan ;

Zhao, Jing ;

Chen, Minjiang ;

Wang, Mengzhao .

CANCER GENE THERAPY, 2024, 31 (05) :652-666

[10] Unravelling key signaling pathways for the therapeutic targeting of non-small cell lung cancer [J].

Chavan, Pavan Ramrao ;

Pandey, Ruchi ;

Patil, Baswant Malesh ;

Murti, Krishna ;

Kumar, Nitesh .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2025, 998

← 1 2 3 4 5 →