Consensus recommendations for the diagnosis and treatment of primary progressive multiple sclerosis in Latin America

被引：5

作者：

Cristiano, Edgardo ^{[1
]}

Ignacio Rojas, Juan ^{[1
]}

Abad, Patricio ^{[2
]}

Adoni, Tarso ^{[3
]}

Barahona, Jorge ^{[4
]}

Becker, Jefferson ^{[5
]}

Carra, Adriana ^{[6
,7
]}

Flores, Jose ^{[8
,9
]}

Fruns, Manuel ^{[10
]}

Fernandez Liguori, Nora ^{[11
,12
]}

Garcea, Orlando ^{[13
]}

Garcia Bonito, Juan ^{[14
]}

Giunta, Diego ^{[15
]}

Gracia, Fernando ^{[16
]}

Hamuy, Fernando ^{[17
,18
]}

Macias Islas, Miguel A. ^{[19
]}

Navas, Carlos ^{[20
]}

Ordonez Boschetti, Liliana ^{[21
]}

Patrucco, Liliana ^{[1
]}

Sato, Douglas K. ^{[5
]}

Correale, Jorge ^{[22
]}

机构：

[1] Hosp Italiano Buenos Aires, Ctr Esclerosis Multiple Buenos Aires, Buenos Aires, DF, Argentina

[2] Hosp Metropolitan Quito, Serv Neurol, Quito, Ecuador

[3] Hosp Sirio Libanes, Multiple Sclerosis Ctr, Sao Paulo, Brazil

[4] Clin Alemana Santiago Chile, Ctr Esclerosis Multiple, Santiago, Chile

[5] Pontifica Catholic Univ Rio Grande Sul PUCRS, Brain Inst Rio Grande Sul, Porto Alegre, RS, Brazil

[6] Hosp Britan Buenos Aires, MS Sect, Buenos Aires, DF, Argentina

[7] INECO, Neurociencias Fdn Favaloro, Buenos Aires, DF, Argentina

[8] Inst Nacl Neurol & Neurocirug, Mexico City, DF, Mexico

[9] Ctr Neurol ABC Santa Fe, Mexico City, DF, Mexico

[10] Clin Las Condes, Santiago, Chile

[11] Hosp Enrique Tornu, Buenos Aires, DF, Argentina

[12] Sanat Guemes, Buenos Aires, DF, Argentina

[13] Hosp Ramos Mejia, Clin Esclerosis Multiple, Buenos Aires, DF, Argentina

[14] Sistema Nacl Salud Colombiano, Clin Marly Bogota, Bogota, Colombia

[15] Hosp Italiano Buenos Aires, Clin Res Sect, Buenos Aires, DF, Argentina

[16] Univ Interamer Panama, Hosp Santo Tomas, Clin Esclerosis Multiple, Serv Neurol, Panama City, Panama

[17] Hosp IMT, Dept Neurol, Asuncion, Paraguay

[18] Dept Neurol Diagnost Codas Thompson, Asuncion, Paraguay

[19] Univ Guadalajara, Ctr Univ Ciencias Salud, Dept Neurociencia, Guadalajara, Jalisco, Mexico

[20] Clin Univ Colombia, Clin Enfermedad Desmielinizante, Bogota, Colombia

[21] Hosp Espanol Mexico, Mexico City, DF, Mexico

[22] FLENI, Inst Neurol Res Dr Raul Carrea, Dept Neurol, Buenos Aires, DF, Argentina

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2018年 / 393卷

基金：

日本学术振兴会;

关键词：

Multiple sclerosis; Primary progressive; Diagnosis; Treatment; Latin America; OUTCOME MEASURES; NATURAL-HISTORY; DOUBLE-BLIND; CLINICAL-TRIALS; MS; PLACEBO; MULTICENTER; MRI; DISABILITY; DEPRESSION;

D O I：

10.1016/j.jns.2018.07.024

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Despite the availability of a large amount of information regarding the management and care of relapsing remitting multiple sclerosis (RRMS) patients, there is scant information about recommendations on how to care for primary progressive MS (PPMS) patients. The objective of this study was to review how PPMS patients should be assessed and cared for in Latin America (LATAM). Methods: A panel of neurology experts from LATAM dedicated to the diagnosis and care of MS patients gathered virtually during 2017 and 2018 to carry out a consensus recommendation on the diagnosis and treatment of PPMS patients in LATAM. To achieve consensus, the methodology of "formal consensus-RAND/UCLA method" was used. Results: Recommendations focused on disease management, and specific and symptomatic disease treatment were determined. The main consensus was that the 2017 McDonald criteria should be used for diagnosis but that the exclusion of regional diseases is strongly recommended; that specific considerations should be taken regarding immunotherapy treatments used in MS due to the scarce evidence available; and that a general approach that considers symptomatic treatment and rehabilitation should be performed in affected patients to improve their status. Conclusions: The recommendations of these consensus guidelines attempt to optimize the health care and management of PPMS patients in LATAM.

引用

页码：4 / 13

页数：10

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