共 37 条
The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM
被引:134
作者:

Paull, TT
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机构:
Univ Texas, Inst Mol & Cellular Biol, Dept Mol Genet & Microbiol, Austin, TX 78712 USA Univ Texas, Inst Mol & Cellular Biol, Dept Mol Genet & Microbiol, Austin, TX 78712 USA

Lee, JH
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机构:
Univ Texas, Inst Mol & Cellular Biol, Dept Mol Genet & Microbiol, Austin, TX 78712 USA Univ Texas, Inst Mol & Cellular Biol, Dept Mol Genet & Microbiol, Austin, TX 78712 USA
机构:
[1] Univ Texas, Inst Mol & Cellular Biol, Dept Mol Genet & Microbiol, Austin, TX 78712 USA
来源:
关键词:
DNA damage;
repair;
sensor;
signaling;
ATM;
Ataxia-Telangiectasia;
D O I:
10.4161/cc.4.6.1715
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Double-strand breaks (DSBs) in chromosomal DNA elicit a rapid signaling response through the ATM protein kinase. Recent evidence suggests that the DNA repair complex containing Mre11, Rad50 and Nbs1 (MRN) is important for the activation of ATM by DSBs in cells. Our studies of the effects of MRN on ATM activity in vitro indicated that MRN stimulates ATM through multiple protein-protein contacts, and that this interaction increases the affinity of ATM for its substrates. Recently we isolated dimeric forms of ATM, which require MRN for activity but also require DNA, similar to the requirements for ATM activation and activity in vivo. Here we discuss the distinct characteristics of dimeric ATM, the role of MRN in recruiting ATM to DNA, the importance of DNA unwinding by MRN, and the role of autophosphorylation in ATM activation.
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页码:737 / 740
页数:4
相关论文
共 37 条
[1]
PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways
[J].
Abraham, RT
.
DNA REPAIR,
2004, 3 (8-9)
:883-887

Abraham, RT
论文数: 0 引用数: 0
h-index: 0
机构:
Burnham Inst, Program Signal Transduct Res, La Jolla, CA 92130 USA Burnham Inst, Program Signal Transduct Res, La Jolla, CA 92130 USA
[2]
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
[J].
Bakkenist, CJ
;
Kastan, MB
.
NATURE,
2003, 421 (6922)
:499-506

Bakkenist, CJ
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA

Kastan, MB
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA
[3]
Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks
[J].
Buscemi, G
;
Perego, P
;
Carenini, N
;
Nakanishi, M
;
Chessa, L
;
Chen, JJ
;
Khanna, K
;
Delia, D
.
ONCOGENE,
2004, 23 (46)
:7691-7700

Buscemi, G
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Perego, P
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Carenini, N
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Nakanishi, M
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Chessa, L
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Chen, JJ
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Khanna, K
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Delia, D
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy
[4]
Chk2 activation dependence on Nbs1 after DNA damage
[J].
Buscemi, G
;
Savio, C
;
Zannini, L
;
Miccichè, F
;
Masnada, D
;
Nakanishi, M
;
Tauchi, H
;
Komatsu, K
;
Mizutani, S
;
Khanna, K
;
Chen, P
;
Concannon, P
;
Chessa, L
;
Delia, D
.
MOLECULAR AND CELLULAR BIOLOGY,
2001, 21 (15)
:5214-5222

Buscemi, G
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Savio, C
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Zannini, L
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Miccichè, F
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Masnada, D
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Nakanishi, M
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Tauchi, H
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Komatsu, K
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Mizutani, S
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Khanna, K
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Chen, P
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

论文数: 引用数:
h-index:
机构:

Chessa, L
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

Delia, D
论文数: 0 引用数: 0
h-index: 0
机构: Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy
[5]
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
[J].
Carney, JP
;
Maser, RS
;
Olivares, H
;
Davis, EM
;
Le Beau, M
;
Yates, JR
;
Hays, L
;
Morgan, WF
;
Petrini, JHJ
.
CELL,
1998, 93 (03)
:477-486

Carney, JP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Sch Med, Genet Lab, Madison, WI 53706 USA

Maser, RS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Sch Med, Genet Lab, Madison, WI 53706 USA

Olivares, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Sch Med, Genet Lab, Madison, WI 53706 USA

Davis, EM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Sch Med, Genet Lab, Madison, WI 53706 USA

Le Beau, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Sch Med, Genet Lab, Madison, WI 53706 USA

Yates, JR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Sch Med, Genet Lab, Madison, WI 53706 USA

Hays, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Sch Med, Genet Lab, Madison, WI 53706 USA

Morgan, WF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Sch Med, Genet Lab, Madison, WI 53706 USA

Petrini, JHJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wisconsin, Sch Med, Genet Lab, Madison, WI 53706 USA Univ Wisconsin, Sch Med, Genet Lab, Madison, WI 53706 USA
[6]
The Mre11 complex is required for ATM activation and the G2/M checkpoint
[J].
Carson, CT
;
Schwartz, RA
;
Stracker, TH
;
Lilley, CE
;
Lee, DV
;
Weitzman, MD
.
EMBO JOURNAL,
2003, 22 (24)
:6610-6620

Carson, CT
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

Schwartz, RA
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

Stracker, TH
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

Lilley, CE
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

Lee, DV
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

Weitzman, MD
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA
[7]
Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization
[J].
Desai-Mehta, A
;
Cerosaletti, KM
;
Concannon, P
.
MOLECULAR AND CELLULAR BIOLOGY,
2001, 21 (06)
:2184-2191

Desai-Mehta, A
论文数: 0 引用数: 0
h-index: 0
机构: Virginia Mason Res Ctr, Mol Genet Program, Seattle, WA 98101 USA

Cerosaletti, KM
论文数: 0 引用数: 0
h-index: 0
机构: Virginia Mason Res Ctr, Mol Genet Program, Seattle, WA 98101 USA

论文数: 引用数:
h-index:
机构:
[8]
ATM-dependent phosphorylation of nibrin in response to radiation exposure
[J].
Gatei, M
;
Young, D
;
Cerosaletti, KM
;
Desai-Mehta, A
;
Spring, K
;
Kozlov, S
;
Lavin, MF
;
Gatti, RA
;
Concannon, P
;
Khanna, K
.
NATURE GENETICS,
2000, 25 (01)
:115-119

Gatei, M
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Brisbane Hosp, Queensland Inst Med Res, Brisbane, Qld, Australia

Young, D
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Brisbane Hosp, Queensland Inst Med Res, Brisbane, Qld, Australia

Cerosaletti, KM
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Brisbane Hosp, Queensland Inst Med Res, Brisbane, Qld, Australia

Desai-Mehta, A
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Brisbane Hosp, Queensland Inst Med Res, Brisbane, Qld, Australia

Spring, K
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Brisbane Hosp, Queensland Inst Med Res, Brisbane, Qld, Australia

Kozlov, S
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Brisbane Hosp, Queensland Inst Med Res, Brisbane, Qld, Australia

Lavin, MF
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Brisbane Hosp, Queensland Inst Med Res, Brisbane, Qld, Australia

Gatti, RA
论文数: 0 引用数: 0
h-index: 0
机构: PO Royal Brisbane Hosp, Queensland Inst Med Res, Brisbane, Qld, Australia

论文数: 引用数:
h-index:
机构:

Khanna, K
论文数: 0 引用数: 0
h-index: 0
机构:
PO Royal Brisbane Hosp, Queensland Inst Med Res, Brisbane, Qld, Australia PO Royal Brisbane Hosp, Queensland Inst Med Res, Brisbane, Qld, Australia
[9]
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest
[J].
Girard, PM
;
Riballo, E
;
Begg, AC
;
Waugh, A
;
Jeggo, PA
.
ONCOGENE,
2002, 21 (27)
:4191-4199

Girard, PM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sussex, MRC, Cell Mutat Unit, Brighton BN1 9RR, E Sussex, England

Riballo, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sussex, MRC, Cell Mutat Unit, Brighton BN1 9RR, E Sussex, England

Begg, AC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sussex, MRC, Cell Mutat Unit, Brighton BN1 9RR, E Sussex, England

Waugh, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Sussex, MRC, Cell Mutat Unit, Brighton BN1 9RR, E Sussex, England

Jeggo, PA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sussex, MRC, Cell Mutat Unit, Brighton BN1 9RR, E Sussex, England Univ Sussex, MRC, Cell Mutat Unit, Brighton BN1 9RR, E Sussex, England
[10]
Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells
[J].
Goodarzi, AA
;
Lees-Miller, SP
.
DNA REPAIR,
2004, 3 (07)
:753-767

Goodarzi, AA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calgary, Canc Biol Res Grp, Dept Biochem & Mol Biol, Calgary, AB T2N 4N1, Canada

Lees-Miller, SP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calgary, Canc Biol Res Grp, Dept Biochem & Mol Biol, Calgary, AB T2N 4N1, Canada