Novel Use of Low-Dose Radiotherapy to Modulate the Tumor Microenvironment of Liver Metastases

被引:21
作者
He, Kewen [1 ,2 ,3 ]
Barsoumian, Hampartsoum B. [3 ]
Bertolet, Genevieve [3 ]
Verma, Vivek [4 ]
Leuschner, Carola [3 ]
Koay, Eugene J. [5 ]
Ludmir, Ethan B. [6 ]
Hsu, Ethan [3 ]
Pisipati, Esha [3 ]
Voss, Tiffany A. [3 ]
Puebla-Osorio, Nahum [3 ]
Cortez, Maria Angelica [3 ]
Welsh, James W. [3 ]
机构
[1] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan, Peoples R China
[2] Shandong Univ, Cheeloo Coll Med, Jinan, Peoples R China
[3] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA
[4] Allegheny Gen Hosp, Dept Radiat Oncol, Pittsburgh, PA 15212 USA
[5] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Radiat Oncol, Houston, TX 77030 USA
[6] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA
关键词
low dose radiation; radiotherapy; immunotherapy; liver cancer; stroma; CANCER-ASSOCIATED FIBROBLASTS; RADIATION; MELANOMA; IRRADIATION;
D O I
10.3389/fimmu.2021.812210
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Despite multiple therapeutic approaches, the presence of liver metastases carries a guarded prognosis, urgently necessitating further clinical and scientific research to develop curative interventions. The liver is an immunoprivileged organ that suppresses the effectiveness of immunotherapies in patients with hepatic metastases. Cancer immunotherapies have been successfully bolstered by low-dose radiotherapy (LDRT), which is capable of reprogramming the tumor microenvironment (TME) from an immunosuppressive to an immunostimulatory one. Likewise, LDRT may be able to revoke the immune privilege enjoyed by the liver, permitting successful immunotherapies there. Here, we first review challenges that face the treatment of liver metastases. We next outline emerging preclinical and clinical evidence supporting enhanced systemic tumor control of LDRT in the context of cancer immunotherapy. Finally, we will discuss the rationale of combining liver-directed LDRT with immunostimulatory strategies to overcome immune resistance and achieve better clinical response. This notion is supported by a recent case study in which a patient who had progressed following T cell therapy experienced a complete response after LDRT to the liver.
引用
收藏
页数:6
相关论文
共 38 条
[1]   The bidirectional crosstalk between metastatic uveal melanoma cells and hepatic stellate cells engenders an inflammatory microenvironment [J].
Babchia, Narjes ;
Landreville, Solange ;
Clement, Bruno ;
Coulouarn, Cedric ;
Mouriaux, Frederic .
EXPERIMENTAL EYE RESEARCH, 2019, 181 :213-222
[2]   Low-dose radiation treatment enhances systemic antitumor immune responses by overcoming the inhibitory stroma [J].
Barsoumian, Hampartsoum B. ;
Ramapriyan, Rishab ;
Younes, Ahmed, I ;
Caetano, Mauricio S. ;
Menon, Hari ;
Comeaux, Nathan, I ;
Cushman, Taylor R. ;
Schoenhals, Jonathan E. ;
Cadena, Alexandra P. ;
Reilly, Timothy P. ;
Chen, Dawei ;
Masrorpour, Fatemeh ;
Li, Ailin ;
Hong, David S. ;
Diab, Adi ;
Nguyen, Quynh-Nhu ;
Glitza, Isabella ;
Ferrarotto, Renata ;
Chun, Stephen G. ;
Cortez, Maria Angelica ;
Welsh, James .
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (02)
[3]   Sites of metastasis and association with clinical outcome in advanced stage cancer patients treated with immunotherapy [J].
Bilen, Mehmet Asim ;
Shabto, Julie M. ;
Martini, Dylan J. ;
Liu, Yuan ;
Lewis, Colleen ;
Collins, Hannah ;
Akce, Mehmet ;
Kissick, Haydn ;
Carthon, Bradley C. ;
Shaib, Walid L. ;
Alese, Olatunji B. ;
Steuer, Conor E. ;
Wu, Christina ;
Lawson, David H. ;
Kudchadkar, Ragini ;
Master, Viraj A. ;
El-Rayes, Bassel ;
Ramalingam, Suresh S. ;
Owonikoko, Taofeek K. ;
Harvey, R. Donald .
BMC CANCER, 2019, 19 (01)
[4]  
Bydder S, 2003, Australas Radiol, V47, P284, DOI 10.1046/j.1440-1673.2003.01177.x
[5]  
Cirri P, 2011, AM J CANCER RES, V1, P482
[6]   Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy [J].
Correia, Ana Luisa ;
Guimaraes, Joao C. ;
Auf Der Maur, Priska ;
De Silva, Duvini ;
Trefny, Marcel P. ;
Okamoto, Ryoko ;
Bruno, Sandro ;
Schmidt, Alexander ;
Mertz, Kirsten ;
Volkmann, Katrin ;
Terracciano, Luigi ;
Zippelius, Alfred ;
Vetter, Marcus ;
Kurzeder, Christian ;
Weber, Walter Paul ;
Bentires-Alj, Mohamed .
NATURE, 2021, 594 (7864) :566-+
[7]   Immunity, tolerance and autoimmunity in the liver: A comprehensive review [J].
Doherty, Derek G. .
JOURNAL OF AUTOIMMUNITY, 2016, 66 :60-75
[8]  
Edyta Wolny-Rokicka, 2015, Asian Pac J Cancer Prev, V16, P6381
[9]  
Folprecht G ., 2016, AM SOC CLIN ONCOL ED, V35, P186, DOI [10.1200/EDBK_159185, DOI 10.1200/EDBK_159185]
[10]  
Griscom JT., 2021, STATPEARLS