A universal biosensing platform based on optical micro-ring resonators

被引：178

作者：

Ramachandran, A. ^{[1
]}

Wang, S. ^{[1
]}

Clarke, J. ^{[1
]}

Ja, S. J. ^{[1
]}

Goad, D. ^{[1
]}

Wald, L. ^{[1
]}

Flood, E. M. ^{[1
]}

Knobbe, E. ^{[1
]}

Hryniewicz, J. V. ^{[1
]}

Chu, S. T. ^{[1
]}

Gill, D. ^{[1
]}

Chen, W. ^{[1
]}

King, O. ^{[1
]}

Little, B. E. ^{[1
]}

机构：

[1] ICx Nomadics, Stillwater, OK 74074 USA

来源：

BIOSENSORS & BIOELECTRONICS | 2008年 / 23卷 / 07期

基金：

欧盟地平线“2020”;

关键词：

micro-ring resonators; biosensor; label-free quantitative detection; optical resonators; whole cell detection; antibody; antigen; nucleic acid; bacteria; IgG; IgM;

D O I：

10.1016/j.bios.2007.09.007

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The use of optical micro-ring resonators as a platform for quantitative and qualitative biosensing applications was explored. Vertically coupled, high refractive index micro-ring resonators, used as sensing elements, were fabricated on silicon chips by photolithographic techniques. An optical reader system consisting of a near-infrared broad band light source and an optical spectrum analyzer were employed for data acquisition. Micro-ring resonator surfaces were modified with specific target receptors, including antibodies and single-stranded DNA oligonucleotides. The system was successfully used for label-free, specific, and rapid detection of whole bacterial cells, proteins and nucleic acids. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：939 / 944

页数：6

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