Antifungal Prophylaxis in Immunocompromised Patients

被引：20

作者：

Vazquez, Lourdes ^{[1
]}

机构：

[1] Hosp Univ Salamanca, Salamanca, Spain

来源：

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES | 2016年 / 8卷

关键词：

INVASIVE FUNGAL-INFECTIONS; STEM-CELL TRANSPLANTATION; LIPOSOMAL AMPHOTERICIN-B; DOUBLE-BLIND TRIAL; NEUTROPENIC PATIENTS; HEMATOLOGIC MALIGNANCIES; PREVENTION; FLUCONAZOLE; MICAFUNGIN; ITRACONAZOLE;

D O I：

10.4084/MJHID.2016.040

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Invasive fungal infections (IFIs) represent significant complications in patients with hematological malignancies. Chemoprevention of IFIs may be important in this setting, but most antifungal drugs have demonstrated poor efficacy, particularly in the prevention of invasive aspergillosis. Antifungal prophylaxis in hematological patients is currently regarded as the gold standard in situations with a high risk of infection, such as acute leukemia, myelodysplastic syndromes, and autologous or allogeneic hematopoietic stem cell transplantation. Over the years, various scientific societies have established a series of recommendations for antifungal prophylaxis based on prospective studies performed with different drugs. However, the prescription of each agent must be personalized, adapting its administration to the characteristics of individual patients and taking into account possible interactions with concomitant medication.

引用

页数：9

共 40 条

[1] Prevention and Treatment of Cancer-Related Infections, Version 2.2016 [J].

Baden, Lindsey Robert ;

Swaminathan, Sankar ;

Angarone, Michael ;

Blouin, Gayle ;

Camins, Bernard C. ;

Casper, Corey ;

Cooper, Brenda ;

Dubberke, Erik R. ;

Engemann, Ashley Morris ;

Freifeld, Alison G. ;

Greene, John N. ;

Ito, James I. ;

Kaul, Daniel R. ;

Lustberg, Mark E. ;

Montoya, Jose G. ;

Rolston, Ken ;

Satyanarayana, Gowri ;

Segal, Brahm ;

Seo, Susan K. ;

Shoham, Shmuel ;

Taplitz, Randy ;

Topal, Jeffrey ;

Wilson, John W. ;

Hoffmann, Karin G. ;

Smith, Courtney .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2016, 14 (07) :882-913

[2] Prevention and Treatment of Cancer-Related Infections [J].

Baden, Lindsey Robert ;

Bensinger, William ;

Angarone, Michael ;

Casper, Corey ;

Dubberke, Erik R. ;

Freifeld, Alison G. ;

Garzon, Ramiro ;

Greene, John N. ;

Greer, John P. ;

Ito, James I. ;

Karp, Judith E. ;

Kaul, Daniel R. ;

King, Earl ;

Mackler, Emily ;

Marr, Kieren A. ;

Montoya, Jose G. ;

Morris-Engemann, Ashley ;

Pappas, Peter G. ;

Rolston, Ken ;

Segal, Brahm ;

Seo, Susan K. ;

Swaminathan, Sankar ;

Naganuma, Maoko ;

Shead, Dorothy A. .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2012, 10 (11) :1412-1445

[3] Comparison of Posaconazole Versus Weekly Amphotericin B Lipid Complex for the Prevention of Invasive Fungal Infections in Hematopoietic Stem-Cell Transplantation [J].

Chaftari, Anne-Marie ;

Hachem, Ray Y. ;

Ramos, Elizabeth ;

Kassis, Christelle ;

Campo, Marcela ;

Jiang, Ying ;

Prince, Randall A. ;

Wang, Weiqun ;

Raad, Issam I. .

TRANSPLANTATION, 2012, 94 (03) :302-308

[4] Safety of a weekly high dose of liposomal amphotericin B for prophylaxis of invasive fungal infection in immunocompromised patients: PROPHYSOME Study [J].

Cordonnier, Catherine ;

Mohty, Mohamad ;

Faucher, Catherine ;

Pautas, Cecile ;

Robin, Marie ;

Vey, Norbert ;

Monchecourt, Francoise ;

Mahi, Lamine ;

Ribaud, Patricia .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2008, 31 (02) :135-141

[5] Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia [J].

Cornely, Oliver A. ;

Maertens, Johan ;

Winston, Drew J. ;

Perfect, John ;

Ullmann, Andrew J. ;

Walsh, Thomas J. ;

Helfgott, David ;

Holowiecki, Jerzy ;

Stockelberg, Dick ;

Goh, Yeow-Tee ;

Petrini, Mario ;

Hardalo, Cathy ;

Suresh, Ramachandran ;

Angulo-Gonzalez, David .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (04) :348-359

[6] Evaluating the role of prophylaxis in the management of invasive fungal infections in patients with hematologic malignancy [J].

Cornely, Oliver A. ;

Aversa, Franco ;

Cook, Perry ;

Jones, Brian ;

Michallet, Mauricette ;

Shea, Thomas ;

Vallejo, Carlos .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2011, 87 (04) :289-301

[7] Primary prophylaxis of invasive fungal infections in patients with hematologic malignancies. Recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology [J].

Cornely, Oliver A. ;

Boehme, Angelika ;

Buchheidt, Dieter ;

Einsele, Hermann ;

Heinz, Werner J. ;

Karthaus, Meinolf ;

Krause, Stefan W. ;

Krueger, William ;

Maschmeyer, Georg ;

Penack, Olaf ;

Ritter, Joerg ;

Ruhnke, Markus ;

Sandherr, Michael ;

Sieniawski, Michal ;

Vehreschild, Joerg-Janne ;

Wolf, Hans-Heinrich ;

Ullmann, Andrew J. .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 (01) :113-122

[8] Primary antifungal prophylaxis in adult patients with acute lymphoblastic leukaemia: a multicentre audit [J].

Doan, Tan N. ;

Kirkpatrick, Carl M. J. ;

Walker, Patricia ;

Slavin, Monica A. ;

Ananda-Rajah, Michelle R. ;

Morrissey, C. Orla ;

Urbancic, Karen F. ;

Grigg, Andrew ;

Spencer, Andrew ;

Szer, Jeffrey ;

Seymour, John F. ;

Kong, David C. M. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2016, 71 (02) :497-505

[9] Management of Drug and Food Interactions with Azole Antifungal Agents in Transplant Recipients [J].

Dodds-Ashley, Elizabeth .

PHARMACOTHERAPY, 2010, 30 (08) :842-854

[10] Comparison of Three Distinct Prophylactic Agents Against Invasive Fungal Infections in Patients Undergoing Haplo-identical Hematopoietic Stem Cell Transplantation and Post-transplant Cyclophosphamide [J].

El-Cheikh, Jean ;

Crocchiolo, Roberto ;

Vai, Andrea ;

Furst, Sabine ;

Bramanti, Stefania ;

Sarina, Barbara ;

Granata, Angela ;

Faucher, Catherine ;

Mohty, Bilal ;

Harbi, Samia ;

Bouabdallah, Reda ;

Vey, Norbert ;

Santoro, Armando ;

Chabannon, Christian ;

Castagna, Luca ;

Blaise, Didier .

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 2015, 7

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