Racial differences in neuromyelitis optica spectrum disorder

被引:133
作者
Kim, Su-Hyun [1 ]
Mealy, Maureen A. [3 ]
Levy, Michael [3 ]
Schmidt, Felix [4 ,5 ,6 ,7 ,8 ,9 ,10 ]
Ruprecht, Klemens [5 ]
Paul, Friedemann [4 ,5 ,6 ,7 ,8 ,9 ,10 ]
Ringelstein, Marius [11 ]
Aktas, Orhan [11 ]
Hartung, Hans-Peter [11 ]
Asgari, Nasrin [12 ,13 ]
Tsz-Ching, Jessica Li [14 ]
Siritho, Sasitorn [15 ]
Prayoonwiwat, Naraporn [15 ]
Shin, Hyun-June [1 ]
Hyun, Jae-Won [1 ]
Han, Mira [2 ]
Leite, Maria Isabel [16 ]
Palace, Jacqueline [16 ]
Kim, Ho Jin [1 ]
机构
[1] Natl Canc Ctr, Res Inst & Hosp, Dept Neurol, Goyang, South Korea
[2] Natl Canc Ctr, Res Inst & Hosp, Biometr Res Branch, Goyang, South Korea
[3] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[4] Charite Univ Med Berlin, NeuroCure Clin Res Ctr, Berlin, Germany
[5] Charite Univ Med Berlin, Dept Neurol, Berlin, Germany
[6] Free Univ Berlin, Berlin, Germany
[7] Humboldt Univ, Berlin, Germany
[8] Berlin Inst Hlth, Berlin, Germany
[9] Max Delbruck Ctr Mol Med, Expt & Clin Res Ctr, Berlin, Germany
[10] Charite Univ Med Berlin, Berlin, Germany
[11] Heinrich Heine Univ, Dept Neurol, Med Fac, Dusseldorf, Germany
[12] Univ Southern Denmark, Dept Neurol, Slagelse Hosp, Odense, Denmark
[13] Univ Southern Denmark, Inst Reg Hlth Res & Mol Med, Odense, Denmark
[14] Queen Elizabeth Hosp, Dept Neurol, Hong Kong, Peoples R China
[15] Mahidol Univ, Siriraj Hosp, Dept Med, Bangkok, Thailand
[16] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford, England
关键词
CLINICAL CHARACTERISTICS; MULTICENTER; AQUAPORIN-4; FEATURES; COHORT; EPIDEMIOLOGY; ASSOCIATION; ANTIBODIES; MYELITIS; NMO;
D O I
10.1212/WNL.0000000000006574
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective We aimed to evaluate racial differences in the clinical features of neuromyelitis optica spectrum disorder. Methods This retrospective review included 603 patients (304 Asian, 207 Caucasian, and 92 Afro-American/Afro-European), who were seropositive for anti-aquaporin-4 antibody, from 6 centers in Denmark, Germany, South Korea, United Kingdom, United States, and Thailand. Results Median disease duration at last follow-up was 8 years (range 0.3-38.4 years). Asian and Afro-American/Afro-European patients had a younger onset age than Caucasian patients (mean 36, 33, and 44 years, respectively; p < 0.001). During the disease course, Caucasian patients (23%) had a lower incidence of brain/brainstem involvement than Asian (42%) and Afro-American/Afro-European patients (38%) (p < 0.001). Severe attacks (visual acuity <= 0.1 in at least one eye or Expanded Disability Status Scale score >= 6.0 at nadir) at onset occurred more frequently in Afro-American/Afro-European (58%) than in Asian (46%) and Caucasian (38%) patients (p = 0.005). In the multivariable analysis, older age at onset, higher number of attacks before and after immunosuppressive treatment, but not race, were independent predictors of severe motor disabilities at last follow-up. Conclusion A review of a large international cohort revealed that race affected the clinical phenotype, age at onset, and severity of attacks, but the overall outcome was most dependent on early and effective immunosuppressive treatment.
引用
收藏
页码:E2089 / E2099
页数:11
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