Medication Complications in Extracorporeal Membrane Oxygenation

被引：9
作者：
Shah, Ami G. [1 ]
Peahota, Michelle [1 ]
Thoma, Brandi N. [1 ]
Kraft, Walter K. [2 ]
机构：
[1] Thomas Jefferson Univ Hosp, Dept Pharm, 111 South 11th St,Suite 2260, Philadelphia, PA 19107 USA
[2] Thomas Jefferson Univ, Dept Pharmacol & Expt Therapeut, 111 South 11th St, Philadelphia, PA 19107 USA
来源：
CRITICAL CARE CLINICS | 2017年 / 33卷 / 04期
关键词：
Pharmacology; Pharmacokinetics; Therapeutic drug monitoring; CRITICALLY-ILL PATIENTS; RESPIRATORY-DISTRESS-SYNDROME; HEPARIN-INDUCED THROMBOCYTOPENIA; NEUROMUSCULAR BLOCKING-AGENTS; PHARMACOKINETIC CHANGES; ANTICOAGULATION MANAGEMENT; MORPHINE PHARMACOKINETICS; OSELTAMIVIR CARBOXYLATE; INTERNATIONAL SURVEY; ENTERAL NUTRITION;
D O I：
10.1016/j.ccc.2017.06.010
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
The need for extracorporeal membrane oxygenation (ECMO) therapy is a marker of disease severity for which multiple medications are required. The therapy causes physiologic changes that impact drug pharmacokinetics. These changes can lead to exposure-driven decreases in efficacy or increased incidence of side effects. The pharmacokinetic changes are drug specific and largely undefined for most drugs. We review available drug-dosing data and provide guidance for use in the ECMO patient population.
引用
收藏
页码：897 / +
页数：25
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