Monitoring of measles elimination using molecular epidemiology

被引：33

作者：

Mulders, MN ^{[1
]}

Truong, AT ^{[1
]}

Muller, CP ^{[1
]}

机构：

[1] WHO, Collaborating Ctr Measles, Dept Immunol, Lab Natl Sante, L-1011 Luxembourg, Luxembourg

来源：

VACCINE | 2001年 / 19卷 / 17-19期

关键词：

measles; genotype; epidemiology;

D O I：

10.1016/S0264-410X(00)00453-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The different measles virus genotypes are confined to more or less distinct geographic regions. Molecular characterization of virus isolates has been successfully used to determine epidemiological links between cases and the geographic origin of imported viruses. In Europe. indigenous measles has been eliminated in some countries, but in others the disease is still endemic. Intra-outbreak variability can be used to differentiate between sporadic endemic cases and a 'pseudo-outbreak' of unrelated imported cases. The interruption of virus circulation by mass vaccination campaigns could be demonstrated by comparing the variability of pre-campaign viruses with post-campaign isolates. Simplified tools are being developed that could bring genotyping within reach of laboratories that do not have the possibility of sequencing. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2245 / 2249

页数：5

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