Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease

被引：39

作者：

Corrales, M

Cardozo, R

Segura, MA

Urbina, JA

Basombrío, MA

机构：

[1] Inst Venezolano Invest Cient, Ctr Bioquim & Biofis, Lab Quim Biol, Carretera Panamericana, Caracas 1020A, Venezuela

[2] Univ Nacl Salta, Fac Ciencias Salud, Lab Patol Expt, Buenos Aires, DF, Argentina

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 04期

关键词：

D O I：

10.1128/AAC.49.4.1556-1560.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas' disease. The results indicated that TAK-187 was more effective than benznidazole in preventing Trypanosoma cruzi-induced cardiac damage in experimental animals.

引用

页码：1556 / 1560

页数：5

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