EVALUATION OF THE EFFICACY OF A NOVEL PERFUSION SOLUTION FOR NORMOTHERMIC EX VIVO LUNG PERFUSION COMPARED WITH STEEN SOLUTION™ (ANIMAL EXPERIMENTAL STUDY)

被引:2
作者
Gautier, S., V [1 ,2 ]
Tsirulnikova, O. M. [1 ,2 ]
Pashkov, I., V [1 ]
Grudinin, N., V [1 ]
Oleshkevich, D. O. [1 ]
Bondarenko, D. M. [1 ]
Mozheiko, N. P. [1 ]
Karpov, A. A. [3 ]
Bunenkov, N. S. [4 ]
机构
[1] Shumakov Natl Med Res Ctr Transplantol & Artifici, Moscow, Russia
[2] Sechenov Univ, Moscow, Russia
[3] Almazov Natl Med Res Ctr, St Petersburg, Russia
[4] Pavlov First St Petersburg State Med Univ, St Petersburg, Russia
来源
VESTNIK TRANSPLANTOLOGII I ISKUSSTVENNYH ORGANOV | 2021年 / 23卷 / 03期
关键词
lung transplantation; donation; ex vivo lung perfusion; TRANSPLANTATION; STATE; EVLP;
D O I
10.15825/1995-1191-2021-3-82-89
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
Respiratory diseases, together with infectious complications and hereditary lung diseases, rank third in international mortality statistics. Today, lung transplantation is a recognized method of treating end-stage lung diseases. However, the number of transplant surgeries performed is not much. This is down to the high requirements on the condition of a potential lung donor and directly on the quality of the donor lung. This has significantly limited the number of optimal donors. Rehabilitation of donor lungs to optimal gas exchange indicators can be achieved and objectively assessed in the course of ex vivo lung perfusion (EVLP). The EVLP procedure is widespread in leading transplantation centers in Europe and North America. It allows to significantly expand the pool of donor lungs, thereby serving a greater number of patients in need of lung transplantation. The possibility of EVLP procedure using publicly available perfusion equipment was demonstrated. The optimized protocol fully demonstrated its reliability and efficiency. The developed perfusion solution had no statistically significant differences in comparison with the Steen Solution (TM), which in the future will serve as an alternative for EVLP procedure.
引用
收藏
页码:82 / 89
页数:8
相关论文
共 22 条
[1]   The Brazilian experience in lung perfusion ex vivo [J].
Abdalla, Luis Gustavo ;
de Oliveira Braga, Karina Andrighetti ;
Nepomuceno, Natalia Aparecida ;
Fernandes, Lucas Matos ;
Samano, Marcos Naoyuki ;
Pego-Fernandes, Paulo Manuel .
JORNAL BRASILEIRO DE PNEUMOLOGIA, 2016, 42 (02) :95-98
[2]   Ex vivo lung perfusion in clinical lung transplantation-State of the art [J].
Andreasson, Anders S. I. ;
Dark, John H. ;
Fisher, Andrew J. .
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2014, 46 (05) :779-788
[3]   Evaluating acellular versus cellular perfusate composition during prolonged exvivo lung perfusion after initial cold ischaemia for 24hours [J].
Becker, Simon ;
Steinmeyer, Jasmin ;
Avsar, Murat ;
Hoeffler, Klaus ;
Salman, Jawad ;
Haverich, Axel ;
Warnecke, Gregor ;
Ochs, Matthias ;
Schnapper, Anke .
TRANSPLANT INTERNATIONAL, 2016, 29 (01) :88-97
[4]  
Briot R., 2016, EX VIVO LUNG GRAFT P
[5]   A new way of monitoring mechanical ventilation by measurement of particle flow from the airways using Pexa method in vivo and during ex vivo lung perfusion in DCD lung transplantation [J].
Broberg E. ;
Wlosinska M. ;
Algotsson L. ;
Olin A.-C. ;
Wagner D. ;
Pierre L. ;
Lindstedt S. .
Intensive Care Medicine Experimental, 6 (1)
[6]   Ex-vivo lung perfusion versus standard protocol lung transplantation-mid-term survival and meta-analysis [J].
Chakos, Adam ;
Ferret, Paule ;
Muston, Benjamin ;
Yan, Tristan D. ;
Tian, David H. .
ANNALS OF CARDIOTHORACIC SURGERY, 2020, 9 (01) :1-+
[7]  
Cypel M, 2015, NEW ENGL J MED, V2, P324, DOI [10.1007/s40472-015-0079-0, DOI 10.1007/S40472-015-0079-0]
[8]  
Jiao G., 2019, SN Compr. Clin. Med, V1, P287, DOI [DOI 10.1007/s42399-019-0046-7, DOI 10.1007/S42399-019-0046-7]
[9]  
Liersch-Nordqvist A, 2017, ANN MED SURG, V22, P1, DOI 10.1016/j.amsu.2017.08.010
[10]   Prolonged EVLP Using OCS Lung: Cellular and Acellular Perfusates [J].
Loor, Gabriel ;
Howard, Brian T. ;
Spratt, John R. ;
Mattison, Lars M. ;
Panoskaltsis-Mortari, Angela ;
Brown, Roland Z. ;
Iles, Tinen L. ;
Meyer, Carolyn M. ;
Helms, Haylie R. ;
Price, Andrew ;
Iaizzo, Paul A. .
TRANSPLANTATION, 2017, 101 (10) :2303-2311