Where do you know what you know? The representation of semantic knowledge in the human brain

被引：1797

作者：

Patterson, Karalyn

Nestor, Peter J.

Rogers, Timothy T.

机构：

[1] MRC Cognit & Brain Sci Unit, Cambridge CB2 7EF, England

[2] Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA

[3] Univ Cambridge, Neurol Unit, Cambridge, England

来源：

NATURE REVIEWS NEUROSCIENCE | 2007年 / 8卷 / 12期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrn2277

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mr M, a patient with semantic dementia-a neurodegenerative disease that is characterized by the gradual deterioration of semantic memory-was being driven through the countryside to visit a friend and was able to remind his wife where to turn along the notrecentlytravelled route. Then, pointing at the sheep in the field, he asked her "What are those things?" Prior to the onset of symptoms in his late 40s, this man had normal semantic memory. What has gone wrong in his brain to produce this dramatic and selective erosion of conceptual knowledge?

引用

页码：976 / 987

页数：12

共 114 条

[1] Semantic dementia and fluent primary progressive aphasia: two sides of the same coin? [J].