The role of intracellular amyloid β in Alzheimer's disease

被引：109
|
作者：
Li, Meng
Chen, Liying
Lee, Daniel Hong Seng
Yu, Long-Chuan
Zhang, Yan
机构：
[1] Peking Univ, Coll Life Sci, Lab Neurobiol, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
[2] Biogen Inc, Cambridge, MA 02142 USA
来源：
PROGRESS IN NEUROBIOLOGY | 2007年 / 83卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; amyloid p peptide; neurotoxicity; neuronal loss;
D O I：
10.1016/j.pneurobio.2007.08.002
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Extracellular amyloid beta (A beta) that confers neurotoxicity and modulates synaptic plasticity and memory function has been central to the amyloid hypothesis of Alzheimer's disease (AD) pathology. Like many other misfolded proteins identified in neurodegenerative disorders, A beta also accumulates inside the AD neurons. This intracellular A beta affects a variety of cellular physiology from protein degradation, axonal transport, autophagy to apoptosis, further documenting the role of A beta in AD. Therapeutics targeting intracellular A beta could be effective treatment for AD. (c) 2007 Elsevier Ltd. All rights reserved.
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页码：131 / 139
页数：9
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