Copper(H) triflate-catalyzed nucleophilic substitution of propargylic acetates with enoxysilanes. A straightforward synthetic route to polysubstituted furans

被引：60

作者：

Zhan, Zhuang-Ping ^{[1
]}

Wang, Shao-Pei

Cai, Xu-Bin

Liu, Hui-Juan

Yu, Jing-Liang

Cui, Yuan-Yuan

机构：

[1] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 13期

关键词：

copper(II) triflate; enoxysilanes; furans; nucleophilic substitution; propargylic acetates;

D O I：

10.1002/adsc.200700234

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel and efficient procedure for the synthesis of gamma-alkynyl ketones by the nucleophilic substitution of propargylic acetates with enoxysilanes in the presence of a catalytic amount of Copper(II) triflate, has been developed. The substitution reaction can be followed by a 4-toluenesulfonic acid-catalyzed cyclization without purification of the gamma-alkynyl ketone intermediates, offering a straightforward synthetic route to polysubstituted furans.

引用

页码：2097 / 2102

页数：6

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