Total Burden of Cerebral Small Vessel Disease on MRI May Predict Cognitive Impairment in Parkinson's Disease

被引：6
作者：
Zhu, Ruihan [1 ,2 ,3 ,4 ]
Li, Yunjing [1 ,3 ,4 ]
Chen, Lina [1 ,3 ,4 ]
Wang, Yingqing [1 ,3 ,4 ]
Cai, Guoen [1 ,3 ,4 ]
Chen, Xiaochun [1 ,3 ,4 ]
Ye, Qinyong [1 ,3 ,4 ]
Chen, Ying [1 ,3 ,4 ]
机构：
[1] Fujian Med Univ, Union Hosp, Fujian Inst Geriatr, Dept Neurol, Fuzhou 350001, Peoples R China
[2] Xiamen Med Coll, Affiliated Hosp 2, Dept Neurol, Xiamen 361021, Peoples R China
[3] Fujian Med Univ, Inst Neurosci, Fujian Key Lab Mol Neurol, Fuzhou 350004, Peoples R China
[4] Fujian Med Univ, Inst Clin Neurol, Fuzhou 350004, Peoples R China
来源：
JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 18期
基金：
中国国家自然科学基金;
关键词：
Parkinson's disease; cerebral small vessel disease burden; cognitive function; WHITE-MATTER HYPERINTENSITIES; STRUCTURAL NETWORK EFFICIENCY; ENLARGED PERIVASCULAR SPACES; MICROBLEEDS; RISK; DEMENTIA; CONNECTIVITY; ASSOCIATION; MULTICENTER; INCIDENT;
D O I：
10.3390/jcm11185381
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
(1) Objective: to investigate the association between the total burden of cerebral small vessel disease (CSVD) and cognitive function in Parkinson's disease (PD). (2) Methods: this retrospective study compared clinical and neuroimaging characteristics of 122 PD patients to determine the association between cognitive decline and total burden of CSVD in PD. All patients underwent brain MRI examinations, and their total CSVD burden scores were evaluated by silent lacunar infarction (SLI), cerebral microbleeds (CMB), white matter hyperintensities (WMH), and enlarged perivascular spaces (EPVS). The cognitive function was assessed by administering Mini-Mental State Examination (MMSE). Receiver-operating characteristic (ROC) curve and the area under the ROC curve (AUC) were performed to quantify the accuracy of the total burden of CSVD and PVH in discriminating PD patients with or without cognitive impairment. (3) Results: the PD patients with cognitive impairment had a significantly higher SLI, CMB, periventricular hyperintensities (PVH), deep white matter hyperintensities (DWMH), enlarged perivascular spaces of basal ganglia (BG-EPVS), and the total CSVD score compared with no cognitive impairment. Total CSVD score and MMSE had a significant negative correlation (r = -0. 483). Furthermore, total burden of CSVD and PVH were the independent risk factors of cognitive impairment in PD, and their good accuracy in discriminating PD patients with cognitive impairment from those with no cognitive impairment was confirmed by the results of ROC curves. (4) Conclusions: total burden of CSVD tightly linked to cognitive impairment in PD patients. The total burden of CSVD or PVH may predict the cognitive impairment in PD.
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页数：13
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