What's new in neuromyelitis optica? A short review for the clinical neurologist

被引：26
作者：
Whittam, Daniel [1 ]
Wilson, Martin [1 ]
Hamid, Shahd [1 ]
Keir, Geoff [1 ]
Bhojak, Maneesh [1 ]
Jacob, Anu [1 ]
机构：
[1] Walton Ctr Neurol & Neurosurg NHS Trust, Lower Lane, Liverpool L9 7LJ, Merseyside, England
来源：
JOURNAL OF NEUROLOGY | 2017年 / 264卷 / 11期
关键词：
Optic neuritis; Myelitis; Aquaporin; Myelin oligodendrocyte glycoprotein; OLIGODENDROCYTE GLYCOPROTEIN ANTIBODIES; INTERLEUKIN-6 RECEPTOR BLOCKADE; STEM-CELL TRANSPLANTATION; SPECTRUM DISORDER; MULTIPLE-SCLEROSIS; DIAGNOSTIC-CRITERIA; COGNITIVE IMPAIRMENT; ASTROCYTIC DAMAGE; ACIDIC PROTEIN; ACUTE RELAPSES;
D O I：
10.1007/s00415-017-8445-8
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The evolution of neuromyelitis optica spectrum disorder (NMOSD) from a rare, incurable and misunderstood disease with almost universally poor outcomes to its present state in just over a decade is unprecedented in neurology and possibly in medicine. Our knowledge of NMOSD biology has led to the recognition of wider phenotypes, new disease mechanisms, and thus clinical trials of new and effective treatments. This article aims to update readers on the recent developments in NMOSD with particular emphasis on clinical advances, the 2015 diagnostic criteria, biomarkers, imaging, and therapeutic interventions.
引用
收藏
页码：2330 / 2344
页数：15
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