Bactericidal antibiotics and oxidative stress: A radical proposal

被引：49

作者：

Hassett, Daniel J. ^{[1
]}

Imlay, James A.

机构：

[1] Univ Cincinnati, Coll Med, Dept Genet Biochem & Microbiol, Cincinnati, OH 45221 USA

[2] Univ Illinois, Dept Microbiol, Urbana, IL 61801 USA

来源：

ACS CHEMICAL BIOLOGY | 2007年 / 2卷 / 11期

关键词：

D O I：

10.1021/cb700232k

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recent publication suggests that many antibiotics exert their bactericidal effects via the production of hydroxyl radicals, regardless of their molecular targets. This proposal represents an abrupt departure from conventional models, and it will attract further experimental tests.

引用

页码：708 / 710

页数：3

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