The effect of coffee, tea, and caffeine consumption on serum uric acid and the risk of hyperuricemia in Korean Multi-Rural Communities Cohort

被引：33

作者：

Bae, Jisuk ^{[1
]}

Park, Pil Sook ^{[2
]}

Chun, Byung-Yeol ^{[3
]}

Choi, Bo Youl ^{[4
]}

Kim, Mi Kyung ^{[4
]}

Shin, Min-Ho ^{[5
]}

Lee, Young-Hoon ^{[6
]}

Shin, Dong Hoon ^{[7
]}

Kim, Seong-Kyu ^{[8
]}

机构：

[1] Catholic Univ Daegu, Dept Prevent Med, Sch Med, Taegu, South Korea

[2] Kyungpook Natl Univ, Dept Food & Nutr, Taegu, South Korea

[3] Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Hlth Promot Res Ctr, Taegu, South Korea

[4] Hanyang Univ, Dept Prevent Med, Coll Med, Seoul 133791, South Korea

[5] Chonnam Natl Univ, Dept Prevent Med, Sch Med, Kwangju, South Korea

[6] Wonkwang Univ, Inst Wonkwang Med Sci, Dept Prevent Med, Coll Med, Iksan, Jeonlabuk Do, South Korea

[7] Keimyung Univ, Dept Prevent Med, Sch Med, Taegu 700712, South Korea

[8] Catholic Univ Daegu, Sch Med, Arthrit & Autoimmun Res Ctr, Div Rheumatol,Dept Internal Med, Taegu 705718, South Korea

来源：

RHEUMATOLOGY INTERNATIONAL | 2015年 / 35卷 / 02期

关键词：

Uric acid; Hyperuricemia; Coffee; Tea; Caffeine; INCIDENT GOUT; INSULIN; HEALTH; NUTRITION; GLUCOSE;

D O I：

10.1007/s00296-014-3061-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Caffeine, a commonly consumed food constituent, is known to exert beneficial physiological effects in humans. There is a lack of comprehensive population data for the effects of caffeine intake on urate metabolism. Therefore, the aim of this study was to determine whether coffee, tea, and caffeine intake influences serum uric acid and the risk of hyperuricemia in the Korean Multi-Rural Communities Cohort. We enrolled 9,400 participants in this study. An assessment of various dietary intake amounts of substances such as coffee and tea was performed using a food frequency questionnaire. The content of caffeine was calculated from coffee (74 mg/cup) and tea (15 mg/cup) intake information from the past year. Multivariate logistic regression models, multiple linear regression models, and analysis of covariance were applied to identify any association of dietary intake with serum uric acid levels or the risk of hyperuricemia. No trends for coffee, tea, or caffeine intake were found according to each quintile with serum uric acid in males, although there were weak, marginally significant trends between the content of coffee and caffeine intake and serum uric acid level in females (p = 0.07 for both). Tea intake in males and caffeine intake in females were significantly different between non-hyperuricemia and hyperuricemia (p = 0.04 and p = 0.04, respectively). In addition, a significant association of serum uric acid level with tea intake in males (beta = 0.0006, p = 0.02) and with tea intake and caffeine intake in females (beta = 0.0003, p = 0.04 and beta = 0.0006, p = 0.02, respectively) was observed. There was no effect of coffee, tea, or caffeine intake on the risk of hyperuricemia in either males or females. This study suggests that caffeine consumption might have an effect on serum uric acid in females. However, coffee, tea, and caffeine intake amounts were not associated with the risk of hyperuricemia.

引用

页码：327 / 336

页数：10

共 25 条

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