The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis

被引：10

作者：

Uyttebroek, Saartje ^{[1
,2
]}

Onsea, Jolien ^{[3
,4
]}

Metsemakers, Willem-Jan ^{[3
,4
]}

Dupont, Lieven ^{[5
,6
]}

Devolder, David ^{[7
]}

Wagemans, Jeroen ^{[8
]}

Lavigne, Rob ^{[8
]}

Spriet, Isabel ^{[7
,9
]}

Van Gerven, Laura ^{[1
,2
,10
]}

机构：

[1] UZ Leuven, Dept Otorhinolaryngol, B-3000 Leuven, Belgium

[2] Katholieke Univ Leuven, Dept Neurosci, Expt Otorhinolaryngol, Rhinol Res, B-3000 Leuven, Belgium

[3] UZ Leuven, Dept Trauma Surg, B-3000 Leuven, Belgium

[4] Katholieke Univ Leuven, Dept Dev & Regenerat, Locomotor & Neurol Disorders, B-3000 Leuven, Belgium

[5] UZ Leuven, Dept Pneumol, B-3000 Leuven, Belgium

[6] Katholieke Univ Leuven, Dept Chron Dis & Metab, Resp Dis & Thorac Surg, B-3000 Leuven, Belgium

[7] UZ Leuven, Pharm Dept, B-3000 Leuven, Belgium

[8] Katholieke Univ Leuven, Lab Gene Technol, Dept Biosyst, B-3000 Leuven, Belgium

[9] Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Clin Pharmacol & Pharmacotherapy, B-3000 Leuven, Belgium

[10] Katholieke Univ Leuven, Allergy & Clin Immunol Res Unit, Dept Microbiol Immunol & Transplantat, B-3000 Leuven, Belgium

来源：

ANTIBIOTICS-BASEL | 2021年 / 10卷 / 06期

关键词：

chronic rhinosinusitis; recalcitrant; refractory; therapy-resistant; bacteriophages; phages; endolysins; phage therapy; PHAGE THERAPY; BIOFILMS; SERA;

D O I：

10.3390/antibiotics10060675

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Chronic rhinosinusitis is a common condition affecting 5-12% of the general population worldwide. In a limited number of cases, the disease is recalcitrant to medical and surgical interventions, causing a major impact on physical, social and emotional well-being and increasing pressure on healthcare systems. Biofilm formation and dysbiosis caused by Staphylococcus aureus and Pseudomonas aeruginosa play a role in the pathogenesis of recalcitrant chronic rhinosinusitis. In these cases, a promising treatment alternative is the application of bacteriophages, which are viruses that infect and lyse bacteria. In this review, we appraise the evidence for the use of bacteriophages in the treatment of recalcitrant chronic rhinosinusitis. Additionally, (dis)advantages of bacteriophages and considerations for implementation of phage therapy in otorhinolaryngology practice will be discussed.

引用

页数：13

共 33 条

[31]

Weber-Dabrowska Beata, 2000, Archivum Immunologiae et Therapiae Experimentalis, V48, P547

[32]

World Health Organization, 2020, GLASS WHOL GEN SEQ S

[33] Bacteriophage effectively kills multidrug resistant Staphylococcus aureus clinical isolates from chronic rhinosinusitis patients [J].