Interactions between lonidamine and β- or hydroxypropyl-β-cyclodextrin

被引：15
|
作者：
Palmieri, GF
Wehrlé, P
Martelli, S
机构：
[1] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, Italy
[2] Fac Pharm Strasbourg, Lab Pharmacotech, F-67401 Illkirch Graffenstaden, France
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1998年 / 24卷 / 07期
关键词：
D O I：
10.3109/03639049809082367
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The possibility of obtaining inclusion complexes between lonidamine and beta- or hydroxypropyl-beta-cyclodextrin have been evaluated by phase solubility diagram, differential scanning calorimetry (DSC), and x-ray diffractometry. The applied complexation methods were spray-drying, kneading, and solid dispersion. DSC and x-ray analyses of the powders revealed an external interaction between lonidamine and cyclodextrins. Dissolution profiles of the obtained powders were also studied to define the most appropriate preparation method and molar ratio to use in attempts to increase lonidamine water solubility.
引用
收藏
页码：653 / 660
页数：8
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